DRSC/TRiP Functional Genomics Resources

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Protein Alignment GC2 and SLC25A13

DIOPT Version :10

Sequence 1:NP_731657.2 Gene:GC2 / 41449 FlyBaseID:FBgn0037970 Length:319 Species:Drosophila melanogaster
Sequence 2:XP_016867152.2 Gene:SLC25A13 / 10165 HGNCID:10983 Length:721 Species:Homo sapiens


Alignment Length:306 Identity:125/306 - (40%)
Similarity:177/306 - (57%) Gaps:38/306 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 GGVAGIIGVACVYPLDMVKTRLQNQ--TIGPNGERMYTSIADCFRKTIASEGYFGMYRGSAVNIV 89
            |.|||.:|...|||:|:||||:|||  |....||.||.:..|||:|.:..||:||:|||....::
Human   381 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLL 445

  Fly    90 LITPEKAIKLTANDFFRYHLASDDGVIPLSRATLAGGLAGLFQIVVTTPMELLKIQMQDAGRVAA 154
            .:.||||||||.|||.|......||.:||:...||||.||..|::.|.|:|::||::|.||.:..
Human   446 GVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITT 510

  Fly   155 ADRAAGREVKTITALGLTKTLLRERGIFGLYKGVGATGVRDITFSMVYFPLMAWI-----NDQGP 214
            ..|        ::||    :::|:.|.||:|||..|..:|||.||.:|||..|.:     |:.| 
Human   511 GPR--------VSAL----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDG- 562

  Fly   215 RKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQA---DGEKKFKGIMDCVNRTLKEEG 276
            :.|.||       .|:||.::||.:|.:|||.||:|||||.   .|:..:.|::||..:.|:|||
Human   563 QVSPGS-------LLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEG 620

  Fly   277 ISAFFKGGLCRIMVLAPLFGIA--------QMFYFLGVGEKILGIE 314
            ..|.:||...|:...:|.||:.        :.||....|.|.:|.|
Human   621 PKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYIDFGGVKPMGSE 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GC2NP_731657.2 Mito_carr 16..106 CDD:395101 43/80 (54%)
Mito_carr 123..203 CDD:395101 31/79 (39%)
Mito_carr 228..302 CDD:395101 31/84 (37%)
SLC25A13XP_016867152.2 EF-hand_7 66..127 CDD:463900
EFh_PEF <102..229 CDD:355382
EF-hand motif 103..129 CDD:320054
EF-hand motif 130..172 CDD:320054
EF-hand motif 179..205 CDD:320054
Mito_carr 375..468 CDD:395101 44/86 (51%)
Mito_carr 470..557 CDD:395101 38/98 (39%)
Mito_carr 562..657 CDD:395101 37/102 (36%)
Blue background indicates that the domain is not in the aligned region.

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