DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC1 and SLC25A12

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_003696.2	Gene:	SLC25A12 / 8604	HGNCID:	10982	Length:	678	Species:	Homo sapiens

Alignment Length:	284	Identity:	123/284 - (43%)
Similarity:	173/284 - (60%)	Gaps:	18/284 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GGIAGIIGVTCVFPLDLVKTRLQNQQIGPN--GERMYNSMFDCFRKTYKAEGYFGMYRGSGVNIL 90
            |.:||.:|.|.|:|:||||||:|||:...:  ||.||.:.||||:|..:.||:||:|||....::
Human   333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLI 397

  Fly    91 LITPEKAIKLTANDYFRHKLTTKDGKLPLTSQMVAGGLAGAFQIIVTTPMELLKIQMQDAGRVAA 155
            .:.||||||||.||:.|.|.|.:||.:||.::::|||.||..|:|.|.|:|::||::|.||.:..
Human   398 GVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITT 462

  Fly   156 AAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSIIYFPLFATLNDLGPRRNDG 220
            ..:::            |..:::|.||||||||..|..|||:.||.||||::|....|   ..|.
Human   463 GPRVS------------ALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLL---LADE 512

  Fly   221 SGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADGEKEFKGISDCITKTLKHEGPTAF 285
            :|.........||..||..||..|.|.||:|||||...:| |:..:.|:.||..|.|:.|||:||
Human   513 NGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPSAF 576

  Fly   286 FKGGLCRMIVIAPLFGIAQTVYYL 309
            :||...|:...:|.||:....|.|
Human   577 WKGTAARVFRSSPQFGVTLVTYEL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	41/78 (53%)
		Mito_carr	115..213	CDD:278578	39/97 (40%)
		Mito_carr	226..307	CDD:278578	33/80 (41%)
SLC25A12	NP_003696.2	N-terminal domain. /evidence=ECO:0000303\|PubMed:25410934	2..294
		EF-hand_7	16..80	CDD:290234
		Linker loop domain. /evidence=ECO:0000303\|PubMed:25410934	295..310
		Carrier domain. /evidence=ECO:0000303\|PubMed:25410934	320..612		123/284 (43%)
		Mito_carr	327..420	CDD:278578	45/86 (52%)
		PTZ00169	330..603	CDD:240302	123/284 (43%)
		Mito_carr	422..513	CDD:278578	41/105 (39%)
		Mito_carr	514..609	CDD:278578	36/88 (41%)
		C-terminal domain. /evidence=ECO:0000303\|PubMed:25410934	613..675
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940