DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GC1 and SLC25A22

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001177989.1	Gene:	SLC25A22 / 79751	HGNCID:	19954	Length:	323	Species:	Homo sapiens

Alignment Length:	319	Identity:	190/319 - (59%)
Similarity:	235/319 - (73%)	Gaps:	24/319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QQFALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPNGERMYNSMFDCFRKTYKAEGYFGM 81
            :|.:|..|:|||||||:||||||||:||.||||||||   ||:|:|.||.||..||.::||||||
Human     4 KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQ---NGQRVYTSMSDCLIKTVRSEGYFGM 65

  Fly    82 YRGSGVNILLITPEKAIKLTANDYFRHKLTTKDG-KLPLTSQMVAGGLAGAFQIIVTTPMELLKI 145
            |||:.||:.|:||||||||.|||:|||:| :||| ||.|..:|:||..||..|:|||||||:|||
Human    66 YRGAAVNLTLVTPEKAIKLAANDFFRHQL-SKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKI 129

  Fly   146 QMQDAGRVAAAAKL------------AGKTVE-----KVSATQLASQLIKDKGIFGLYKGIGATG 193
            |:|||||:||..|:            |..:||     :.:||||...|::.:||.|||||:|||.
Human   130 QLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATL 194

  Fly   194 LRDVTFSIIYFPLFATLNDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIK 258
            ||||.||::||||||.||.||  |.....::.|:.|||||..|||.||:||||.||||||||:::
Human   195 LRDVPFSVVYFPLFANLNQLG--RPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQ 257

  Fly   259 KADGEKEFKGISDCITKTLKHEGPTAFFKGGLCRMIVIAPLFGIAQTVYYLGVAEGLLG 317
            :...|..:.||.||..|.|:||||:||.||..||.:||||||||||.||:||:||.|||
Human   258 RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLG 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	53/76 (70%)
		Mito_carr	115..213	CDD:278578	61/115 (53%)
		Mito_carr	226..307	CDD:278578	50/80 (63%)
SLC25A22	NP_001177989.1	Mito_carr	4..98	CDD:278578	66/97 (68%)
		Solcar 1	6..93		62/89 (70%)
		Mito_carr	99..208	CDD:278578	55/108 (51%)
		Solcar 2	101..214		59/112 (53%)
		Mito_carr	221..306	CDD:278578	50/84 (60%)
		Solcar 3	223..312		54/88 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4922
eggNOG	1	0.900	-	-		E1_KOG0750
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69383
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2233
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S1412
OMA	1	1.010	-	-		QHG53612
OrthoDB	1	1.010	-	-		D458796at33208
OrthoFinder	1	1.000	-	-		FOG0002230
OrthoInspector	1	1.000	-	-		mtm8446
orthoMCL	1	0.900	-	-		OOG6_104895
Panther	1	1.100	-	-	O	PTHR45678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	1	1.000	-	-		X982
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820