Protein Alignment GC1 and Slc25a12

DIOPT Version :10

• Sequence 1: NP_650134.1
• Gene: GC1 / 41448
• FlyBaseID: FBgn0260743
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_766024.1
• Gene: Slc25a12 / 78830
• MGIID: 1926080
• Length: 677
• Species: Mus musculus
• Alignment Length: 1417
• Identity: 268/1417 - (18%)
• Similarity: 452/1417 - (31%)
• Gaps: 431/1417 - (30%)

  Fly   329 RRTTDSDQQDGKAGPPPPVIEISKAEQARRTE-EYLRVKSEDDKILAKHGFTRKPEPSIEIQEPV 392
            :|..:..:|..|...|.|.:...|.  .|.|| .:|||..             .|.|.:| :|.|
Mouse   457 KRLRELSEQLYKNENPNPHMAFQKV--PRPTEGSHLRVHV-------------VPFPMLE-EERV 505

  Fly   393 TEQIRDDVVETAIAPEVPLRPVEELPHSPAPSSRSTPATTPKLSAKFRKDGKEGKPFDFGKSKFV 457
            .|.|::.:.:...|| |..||.::.         ..||..|.:|..    ||....|:..:...|
Mouse   506 EELIQEGLAKQHSAP-VSTRPEKKC---------VVPAGPPVVSIM----GKASSVFNSARRLEV 556

  Fly   458 CKHDV--IKRGKEVEVKLEGIKLGKEDQLRVVVLPPANKAIPGANGGPPTEVDTKVKKSSSKYEI 520
            .:..:  |...|.:|.:              ..||.|.:|:.|           |..:.....|:
Mouse   557 VRTCIGFIFDNKTLETE--------------KTLPAALRALKG-----------KAARQCLTEEL 596

  Fly   521 SFKPTE---VGTHKVFAYVNDMQHPLSPFAVRVYDASEIIVGEIPNQSNLNDTVEFTVDAGRAGF 582
            |....:   :..|:.|.::..|.:    .|::...:||                |:||.|
Mouse   597 SHHVQQNRAILDHQQFDHIVRMMN----CALQDCSSSE----------------EYTVAA----- 636

  Fly   583 GNLEMAIKDADGVIIPSHVA---QLESGSAKFLVTFTPATKGPHTVN-----ITFNKEVLK---- 635
                        .::|...|   :|.:|..:|  .:|...:.|...|     .||..||..
Mouse   637 ------------ALLPLTTAFYRKLAAGVDQF--AYTCIQEHPIWTNQQFWEATFYSEVQNQIRA 687

  Fly   636 ---NSPFEVNIVDAPLPAPVVLEPASGASAVASPSLSKKEL-------KEQEKEKKREEKERAKR 690
               .:|.:..::.|.:..|..|..|:|.|...:..|:.::|       ||::.|..:.|:.....
Mouse   688 LYLTAPEDKPLITAKIKEPSRLSTAAGQSERTAMDLAAEQLRAWPGLSKEKQHELVKSEESTVFS 752

  Fly   691 EKEERATL----------KKEKKSKSHRFPA---KTTVSKIPSLSRVGQPSSLVVEVSGHDQLEI 742
            :....|:|          .|.|..:|:  ||   ::..:.|.:.|..|..:......||.:..|.
Mouse   753 QAIHYASLMVYLLVPLDTSKNKLLRSN--PAADWESGSNSILTNSIAGSVAESFDTESGFEDSET 815

  Fly   743 ------------RVLDSKKSEIGTDIVEIEPGHMQI-NFTPAQVGDHEIDVRYG-GVPVTGSPFT 793
                        |.:|...:|.|.....|:..|..| .....|:...|:..|.. .:|....|..
Mouse   816 SDVANSVGRFISRFIDKVCTESGVTQDHIKSLHSMIPGIVAMQMETLEVVHRESRRLPPIQKPKI 880

  Fly   794 CR-AYDPAKIKVGAIPKGLLDKPVYFTVDASEAGVGNLEVAVCEGRVPSMAHALGHHKYDISFVP 857
            .| |..|.:..|....:.:||.      |..|...|.|              ..|.|     .:|
Mouse   881 LRPALLPGEELVSEGLRVVLDP------DGREEATGGL--------------LGGPH-----ILP 920

  Fly   858 KEDVDHTITVRFNNEPVPGSPFLCQLVATAQATATGAGLERIPVDEETEIQILTDEIDSAPEARV 922
            .|......|.|...:..|..|.:.:     ||.     :...||...|:.:.:|.:
Mouse   921 AEGALFLTTYRIVFKGTPHDPLVGE-----QAV-----IRSFPVSTLTKEKKITIQ--------- 966

  Fly   923 RDPQGNDLPVNV-----TRSRENETLHIATYVPKCVGNHLIDIF---LQGEPIAGSPFTAKAYDA 979
                 |.|..|:     .||...:.:.:|  ..:.|.:.:::||   :|......|.|:..|:.|
Mouse   967 -----NQLQQNMQEGLQLRSASFQLIKVA--FDEEVSSEMVEIFRKHVQRIRYPSSIFSTFAFAA 1024

  Fly   980 RKTV--LVPPAN-------AVVGKPATFVIDAARSGAGNM---------------------EIIV 1014
            .:|.  |:.|..       ..:.|  |.|..|.::|...|                     :|.:
Mouse  1025 GQTAPQLILPKQKERNTGFRTLSK--TIVKGAIKAGKITMGRQSTLKKNEKGSRMTWHEDDDISI 1087

  Fly  1015 SVDNRNVP--NFVQAEGQARFKVSFTPQDAKDH------TISVKFNGISVPGSPLICSV----SS 1067
            | |:...|  |.::|..::..:........:|:      |||.....:.......:.:|    |.
Mouse  1088 S-DDGEPPSSNTLKASEKSTMEQLVERACFRDYQRLGLGTISANSTRLKSGEQFRVTAVNRLYSL 1151

  Fly  1068 AGSVPAAVVLPAAAVIGAETAVAARERIKHTPQHSSEQ------IKQTTTTVLQKTPEIRETVEK 1126
            ..|.|..:|:|                  ||.|.||.|      .......|..|.|..:..:.:
Mouse  1152 CRSYPGLLVIP------------------HTVQDSSLQKVSRCYRHNRLPVVCWKHPRTKAVLLR 1198

  Fly  1127 T---------GLARELNSAQIGQKKGFTIDNINKSSDCNVIITAPDGSMVPVSIQKSSTSAYAEF 1182
            :         ||.:..|.:........|..::.:......|:     |.:|:..:.:.::
Mouse  1199 SGGFHSKSVVGLFKSQNPSSAAPTSSDTSSSLEQEKYLQAIL-----SSIPIYFKPNGSN----- 1253

  Fly  1183 TPTITGEHLV-----------------EIYLDHEIIDEFVIKIKDERHILPPVCLAGQKYSFDVN 1230
              |:|...|:                 .::||....:.|.      |.:|      |.:.....:
Mouse  1254 --TLTNRSLIGLSPASERRASRIPKMAPVHLDISFTNSFT------RGVL------GYRDKLFTH 1304

  Fly  1231 SDDKNKVRVTIREPSGRMLPVQMEDLPDGGVRVSCRFKEVGIHSIDVFVDDQPIGERKMQ----- 1290
            |:.|...:       ||        :.:.||..|.|       |...|:....:|:...:
Mouse  1305 SNQKASAK-------GR--------IHNQGVWASLR-------SSSRFIQHPAVGDVGARLAGKD 1347

  Fly  1291 ----TVIDPLNGAQLVSEPKREIVGEQTELK-ILIDSGVESQVEVIIEGPDREDNEVFVKKVSET 1350
                |.|:.|....|..:....|.||::..: :.:|..:..:: |.:|..|....:...||
Mouse  1348 LAPPTGIENLQAQLLKHQAALYIFGEKSHFRGLKLDPALNCEL-VPVEFADTRQVKASFKK---- 1407

  Fly  1351 LWSAVWTPKVEGEHELSILVAGEQIPGSPFPIHVLDPSAVRVIGL--KNAPVGVEQQFSVDYTNS 1413
            |..|.....:..:.|.|.|.|.|:.... ..||.|...||..:.|  ..:.|.|..:...|.|..
Mouse  1408 LLRACAPSAMSSDTEDSFLKALEESEWM-LQIHKLLQLAVVAVELLDSGSSVLVSLEEGWDITTQ 1471

  Fly  1414 GASIASV------EVRHGDQTIPITVKK--------------MKPGQLLCTFTP----FVDGPHQ 1454
            ..|:..|      ....|.|   :.::|              :.|......|||    |:|..||
Mouse  1472 VVSLTQVLSDPFYRTLEGFQ---VLLEKEWLSFGHKFSQRGNLNPNSQGSGFTPIFLQFLDCVHQ 1533

  Fly  1455 VEVIIDGVPLS-------------------------DGPYEVFISHLGTVRASGDALRKAQRART 1494
            |.   :..||.                         |..|| .:.| ||:  ..|...|..:...
Mouse  1534 VH---NQYPLEFEFNQYYLKFLAYHYVSNRFKNFLLDSDYE-RLEH-GTL--FEDKGEKQSKRGI 1591

  Fly  1495 ARFEVINVEQNRGEL--DVMVSDPKGGPLPVRCYKQQDDSYWVEFTPEHLGT 1544
            ..:|.||....:|.|  :.:.|..:..|:........:.:.|..:|.|.|.|
Mouse  1592 CIWECINRMHRKGPLFFNYLYSPSETEPVLKPLISIPNLTTWEFYTGETLST 1643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_650134.1	PTZ00169	37..294	CDD:240302
Slc25a12	NP_766024.1	Regulatory N-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746	2..294
		FRQ1	12..125	CDD:444056
		Linker loop domain. /evidence=ECO:0000250|UniProtKB:O75746	295..310
		Carrier domain. /evidence=ECO:0000250|UniProtKB:O75746	320..612		44/209 (21%)
		Mito_carr	327..420	CDD:395101
		Mito_carr	422..513	CDD:395101	19/71 (27%)
		Mito_carr	519..609	CDD:395101	24/128 (19%)
		C-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746	613..677		16/102 (16%)