Protein Alignment GC1 and UCP2

DIOPT Version :10

• Sequence 1: NP_650134.1
• Gene: GC1 / 41448
• FlyBaseID: FBgn0260743
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 945
• Identity: 171/945 - (18%)
• Similarity: 275/945 - (29%)
• Gaps: 345/945 - (36%)

  Fly   419 HSPAPSSRSTPATTPKLSAKFRKDGKEGKPFDFGKSKFV---------CKHDV--IKRG---KEV 469
            |.|..::|..||  |:|.|:...:..|.:|. .|..|.:         |..|:  ::.|   |.:
Human   120 HGPVRAARILPA--PQLGAQKCDNFAEKRPL-LGVCKSIGSSGTTPPYCCVDLYSLRTGEMVKSI 181

  Fly   470 EVKLEGIKLGKEDQLRVVVLPPANKAI-----------------PGANGGP-------------- 503
            :.|.....|....::.||||.....|.                 ||.|..|
Human   182 QFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENK 246

  Fly   504 -------------------PTEVDTKVKKSSSKYEISFK---------PTEVGTHKVFAYVNDMQ 540
                               ...|.:..|...|...:..|         |:.|....:..:.|..:
Human   247 LIRCHQSRGGACGDNIQSYTATVISAAKTLKSGLTMVGKVVTQLTGTLPSGVTDDDIAIHCNSRR 311

  Fly   541 HPLSPFAVRVYDASEIIVGEIPNQSNLNDTVEFTVDAGRAGFGNLEMAIKDADGVI--IPSH--- 600
            .||.|..:.|.|...:..|::                       |.....|:||::  .|:|
Human   312 SPLVPGIITVIDTETVGEGQV-----------------------LVSEDSDSDGIVAHFPAHEKP 353

  Fly   601 -VAQLESGSAKFLVTFTPATKGPHTVNI-----------TFNKEVLKNSPFEVNIVDAPLPAP-- 651
             .....:.|...|||........|...|           ..:...|.....|..:.|......
Human   354 VCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKVQDICFSHDCR 418

  Fly   652 -VVLEPASGASAV-------ASPSLSKKELKEQEKEKKREEKERAKREKEERATLKKEKKSKSHR 708
             ||:....|.|.|       ..|.:.............|.:|.....|.|:..|.|:..:
Human   419 WVVVSTLRGTSHVFPINPYGGQPCVRTHMSPRVVNRMSRFQKSAGLEEIEQELTSKQGGR----- 478

  Fly   709 FPAKTTVSKIPSLSRVGQPSSLVVEVSGHDQLEIRVLDSKKSEIGTDIVEIEPGHMQINFTP--- 770
                  .|.:|.||.....|.|..::|..|..             .:.....||:.:::..|
Human   479 ------CSPVPGLSSSPSGSPLHGKLSSQDSY-------------NNFTNNNPGNPRLSPLPSLM 524

  Fly   771 -----AQVGDHEIDVRYGGVPVTGSPF-----------TCRAYDPAKIKVGAIPKGLLDKPVYFT 819
                 ||:   :..:..|.:.....|:           .|:...|.:|.......|.......|.
Human   525 VVTPLAQI---KQPMTLGTITKRTGPYLFGAGCFSIKAPCKVKPPPQISPSKSMGGEFCVAAVFG 586

  Fly   820 VD----ASEAG------------VGNLEVAVCEGRVPSMAHALGHHKYDISFVPKEDVDHTITVR 868
            ..    |:.||            |.:|.:..|.|.:                     |:|.|
Human   587 TSRSWFANNAGLKREKDQSKQVVVESLYIISCYGTL---------------------VEHMI--- 627

  Fly   869 FNNEPVPGSPFLCQLVATAQATATGAGLERIPVDEETEIQILTDEIDSAPEAR---VRDPQGNDL 930
               ||.|        ::||.           .:.::|.::|:|     :|.|.   ||.||.|:|
Human   628 ---EPRP--------ISTAP-----------KISDDTPLEIMT-----SPRASWTLVRTPQWNEL 665

  Fly   931 --PVNVTRSRENETLHIATYVPKCVGNHLIDIFLQGEPIAGSPFTAK---AYDARKTVLVPPANA 990
              |.|.     |..|.:|....:     ...:.|.|....|||....   :||:
Human   666 QPPFNA-----NHPLLLAAEAVQ-----YYQLLLAGSLPPGSPGPITRHGSYDS----------- 709

  Fly   991 VVGKPATFVIDAARSGAGNMEIIVSVD-------NRNV---PNF----VQAEGQA---------- 1031
                     :.:..||..:.|.:..|:       :|.:   |.|    :...||.
Human   710 ---------LASDHSGQEDEEWLSQVEIVTHTGPHRRLWMGPQFQFKTIHPSGQTTVISSSSSVL 765

  Fly  1032 -RFKVSFTPQ-----DAKDHTIS------VKFNGISVPGS--PL-----ICSV--SSAGSVPAAV 1075
             ....|.|||     |..|..::      |:.:.:|:|||  |:     :.:|  :::|:...:|
Human   766 QSHGPSDTPQPLLDFDTDDLDLNSLRIQPVRSDPVSMPGSSRPVSDRRGVSTVIDAASGTFDRSV 830

  Fly  1076 VLPAAAVIGA--------------ETAVAARERIKHTPQHSSEQ--IKQTTTTVL-----QKTPE 1119
            .|  ..|.|:              .|....|||:......|..:  :...|.|.|     ..|||
Human   831 TL--LEVCGSWPEGFGLRHMSSMEHTEEGLRERLADAMAESPSRDVVGSGTDTALDVAVKNSTPE 893

  Fly  1120 IRETVEKTGLARELNSAQIGQKKGFTIDNINKSSD 1154
            ....|:...|.||.:...:....|.|..:|.::.|
Human   894 RHMAVKCLELQREGSIETLSNSSGSTSGSIPRNFD 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_650134.1	PTZ00169	37..294	CDD:240302
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63
		transmembrane domain	17..34
		transmembrane domain	78..100
		Mito_carr	112..206	CDD:395101	22/88 (25%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		22/85 (26%)
		transmembrane domain	120..137		7/18 (39%)
		transmembrane domain	174..197		4/22 (18%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		9/84 (11%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	9/81 (11%)
		purine nucleotide binding domain	264..273		1/8 (13%)
		transmembrane domain	269..291		4/21 (19%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)