DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC1 and Slc25a18

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001037745.2	Gene:	Slc25a18 / 681896	RGDID:	1590470	Length:	320	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	161/314 - (51%)
Similarity:	215/314 - (68%)	Gaps:	20/314 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QQFALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPNGERMYNSMFDCFRKTYKAEGYFGM 81
            |..::..|:|||||||::|||||||:||.||||||||    |:.:|..|.||..||.:|||:.||
  Rat     9 QDLSITAKLINGGIAGLVGVTCVFPIDLAKTRLQNQQ----GKDVYKGMTDCLVKTARAEGFLGM 69

  Fly    82 YRGSGVNILLITPEKAIKLTANDYFRHKLTTKDGKLPLTSQMVAGGLAGAFQIIVTTPMELLKIQ 146
            |||:.||:.|:||||||||.|||:.|..|.....:..|..:|:||..||..|:::|.|||:||||
  Rat    70 YRGAAVNLTLVTPEKAIKLAANDFLRQLLMQDGTQRNLKMEMLAGCGAGICQVVITCPMEMLKIQ 134

  Fly   147 MQDAGRVAAAAKLAG--------------KTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDV 197
            :|||||:|...:.:.              .|..:.|||.:|.:|::.:|:.|||:|:|||.|||:
  Rat   135 LQDAGRLAVCQQASASATPTSRPYSTGSTSTHRRPSATLIAWELLRTQGLSGLYRGLGATLLRDI 199

  Fly   198 TFSIIYFPLFATLNDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADG 262
            .||||||||||.||.||.  ::.:|:|.|..||:||.||||.:|:||.|.||:|||:|.:||..|
  Rat   200 PFSIIYFPLFANLNQLGV--SELTGKASFTHSFVAGCAAGSVSAVAVTPLDVLKTRIQTLKKGLG 262

  Fly   263 EKEFKGISDCITKTLKHEGPTAFFKGGLCRMIVIAPLFGIAQTVYYLGVAEGLL 316
            |..::|::||..|....||..||.||..||.:||||||||||.||::|:.|.:|
  Rat   263 EDTYRGVTDCARKLWTQEGAAAFMKGAGCRALVIAPLFGIAQGVYFIGIGERIL 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	47/76 (62%)
		Mito_carr	115..213	CDD:278578	50/111 (45%)
		Mito_carr	226..307	CDD:278578	45/80 (56%)
Slc25a18	NP_001037745.2	Mito_carr	9..102	CDD:395101	57/96 (59%)
		Solcar 1	11..97		55/89 (62%)
		Solcar 2	105..215		50/109 (46%)
		Mito_carr	111..209	CDD:395101	44/97 (45%)
		Mito_carr	222..307	CDD:395101	47/84 (56%)
		Solcar 3	224..313		49/88 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4758
eggNOG	1	0.900	-	-		E1_KOG0750
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2180
OMA	1	1.010	-	-		QHG53612
OrthoDB	1	1.010	-	-		D458796at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8923
orthoMCL	1	0.900	-	-		OOG6_104895
Panther	1	1.100	-	-	LDO	PTHR45678
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X982
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840