Protein Alignment GC1 and SLC25A6

DIOPT Version :10

• Sequence 1: NP_650134.1
• Gene: GC1 / 41448
• FlyBaseID: FBgn0260743
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_001627.2
• Gene: SLC25A6 / 293
• HGNCID: 10992
• Length: 298
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 70/284 - (24%)
• Similarity: 118/284 - (41%)
• Gaps: 26/284 - (9%)

  Fly    17 QQFALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPN--GERMYNSMFDCFRKTYKAEGYF 79
            |..:.....:.||||..|..|.|.|::.||..||.|.....  .::.|..:.||..:..|.:|..
Human     4 QAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVL 68

  Fly    80 GMYRGSGVNILLITPEKAIKLTANDYFRHKLTTKDGKLPLTSQ--------MVAGGLAGAFQIIV 136
            ..:||:..|::...|.:|:.....|.::....   |.:...:|        :.:||.|||..:..
Human    69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFL---GGVDKHTQFWRYFAGNLASGGAAGATSLCF 130

  Fly   137 TTPMELLKIQMQDAGRVAAAAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSI 201
            ..|::..:.      |:||....:|...|.........::.|..||.|||:|...:....:.:..
Human   131 VYPLDFART------RLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189

  Fly   202 IYFPLFATLNDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTR--LQAIKKADGEK 264
            .||.::.|...:.|   |.....:. .|::......:.|.:...|||.|:.|  :|:.:|. .:.
Human   190 AYFGVYDTAKGMLP---DPKNTHIV-VSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKG-ADI 249

  Fly   265 EFKGISDCITKTLKHEGPTAFFKG 288
            .:.|..||..|..:.||..|||||
Human   250 MYTGTVDCWRKIFRDEGGKAFFKG 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_650134.1	PTZ00169	37..294	CDD:240302	64/264 (24%)
SLC25A6	NP_001627.2	PTZ00169	3..298	CDD:240302	70/284 (25%)
		Solcar 1	6..98		24/91 (26%)
		Solcar 2	111..201		21/95 (22%)
		Solcar 3	212..297		20/63 (32%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		1/4 (25%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		1/4 (25%)