Protein Alignment GC1 and SLC25A5

DIOPT Version :10

• Sequence 1: NP_650134.1
• Gene: GC1 / 41448
• FlyBaseID: FBgn0260743
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_001143.2
• Gene: SLC25A5 / 292
• HGNCID: 10991
• Length: 298
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 69/273 - (25%)
• Similarity: 112/273 - (41%)
• Gaps: 26/273 - (9%)

  Fly    28 GGIAGIIGVTCVFPLDLVKTRLQNQQIGP--NGERMYNSMFDCFRKTYKAEGYFGMYRGSGVNIL 90
            ||:|..|..|.|.|::.||..||.|....  ..::.|..:.||..:..|.:|....:||:..|::
Human    15 GGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVI 79

  Fly    91 LITPEKAIKLTANDYFRHKLTTKDGK-----LPLTSQMVAGGLAGAFQIIVTTPMELLKIQM-QD 149
            ...|.:|:.....|.::........|     |.....:.:||.|||..:....|::..:.:: .|
Human    80 RYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAAD 144

  Fly   150 AGRVAAAAKLAGKTVEKVSATQLASQLI---KDKGIFGLYKGIGATGLRDVTFSIIYFPLFATLN 211
            .|:..|..:..|          |...|:   |..||.|||:|...:....:.:...||.::.|..
Human   145 VGKAGAEREFRG----------LGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAK 199

  Fly   212 DLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADG-EKEFKGISDCITK 275
            .:.|   |.....:. .|::......:.|.|...|||.|:.|:.......| :..:.|..||..|
Human   200 GMLP---DPKNTHIV-ISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRK 260

  Fly   276 TLKHEGPTAFFKG 288
            ..:.||..|||||
Human   261 IARDEGGKAFFKG 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_650134.1	PTZ00169	37..294	CDD:240302	65/264 (25%)
SLC25A5	NP_001143.2	Solcar 1	6..98		23/82 (28%)
		PTZ00169	7..296	CDD:240302	69/273 (25%)
		Solcar 2	111..201		23/99 (23%)
		Solcar 3	212..297		20/62 (32%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		1/4 (25%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		1/4 (25%)