DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC1 and slc-25A18.1

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_510493.2	Gene:	slc-25A18.1 / 181596	WormBaseID:	WBGene00008979	Length:	313	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	183/310 - (59%)
Similarity:	229/310 - (73%)	Gaps:	15/310 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPNGERMYNSMFDCFRKTYKAEG------ 77
            |:..|||:|||:||||||:||||:||||||||||.:|.:|:..|:.:.||.::|:::.|
Worm     7 FSYGPKIMNGGLAGIIGVSCVFPIDLVKTRLQNQTVGADGKLQYSGIADCAKQTWRSGGASTLAK 71

  Fly    78 YFGMYRGSGVNILLITPEKAIKLTANDYFRHKLTTKDG--KLPLTSQMVAGGLAGAFQIIVTTPM 140
            :.|||.|||||||||||||||||.|||:||||| .|:|  :|.:...|:||||||.|||.|||||
Worm    72 FRGMYSGSGVNILLITPEKAIKLVANDFFRHKL-AKEGEKQLSVGRGMLAGGLAGMFQISVTTPM 135

  Fly   141 ELLKIQMQDAGRVAAAAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSIIYFP 205
            |||||||||.||.....:      :|:|||||..:|:|:.||..||||:.:|..||||||:||||
Worm   136 ELLKIQMQDQGRTLKPGQ------QKLSATQLTMKLVKENGIAALYKGLSSTLARDVTFSVIYFP 194

  Fly   206 LFATLNDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADGEKEFKGIS 270
            |||.|:.|.||:.||||:|||:.||||||.:|:.::..|.|.||:|||:|.|.|...|..:|.|.
Worm   195 LFAYLDSLAPRKPDGSGDAVFYGSFLAGLTSGAASSFCVTPLDVIKTRMQTINKGANEIVYKNIP 259

  Fly   271 DCITKTLKHEGPTAFFKGGLCRMIVIAPLFGIAQTVYYLGVAEGLLGYQK 320
            |......|:|||.|.|||..|||:|:||||||||||||:||||.:||.||
Worm   260 DAFVTIFKNEGPKALFKGAACRMMVMAPLFGIAQTVYYIGVAEKILGIQK 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	50/82 (61%)
		Mito_carr	115..213	CDD:278578	57/99 (58%)
		Mito_carr	226..307	CDD:278578	43/80 (54%)
slc-25A18.1	NP_510493.2	PTZ00169	3..278	CDD:240302	158/277 (57%)
		Mito_carr	5..108	CDD:278578	63/101 (62%)
		Mito_carr	110..199	CDD:278578	55/94 (59%)
		Mito_carr	215..296	CDD:278578	43/80 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167848
Domainoid	1	1.000	128	1.000	Domainoid score	I3298
eggNOG	1	0.900	-	-		E1_KOG0750
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69383
Inparanoid	1	1.050	352	1.000	Inparanoid score	I1327
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S1412
OMA	1	1.010	-	-		QHG53612
OrthoDB	1	1.010	-	-		D458796at33208
OrthoFinder	1	1.000	-	-		FOG0002230
OrthoInspector	1	1.000	-	-		mtm4728
orthoMCL	1	0.900	-	-		OOG6_104895
Panther	1	1.100	-	-	LDO	PTHR45678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	1	1.000	-	-		X982
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790