DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC1 and SLC25A13

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_006715894.1	Gene:	SLC25A13 / 10165	HGNCID:	10983	Length:	686	Species:	Homo sapiens

Alignment Length:	289	Identity:	123/289 - (42%)
Similarity:	173/289 - (59%)	Gaps:	28/289 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GGIAGIIGVTCVFPLDLVKTRLQNQQIGPN--GERMYNSMFDCFRKTYKAEGYFGMYRGSGVNIL 90
            |.:||.:|.|.|:|:||||||:|||:...:  ||.||.:.||||:|..:.||:||:|||....:|
Human   346 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLL 410

  Fly    91 LITPEKAIKLTANDYFRHKLTTKDGKLPLTSQMVAGGLAGAFQIIVTTPMELLKIQMQDAGRVAA 155
            .:.||||||||.||:.|.|...|||.:||.::::|||.||..|:|.|.|:|::||::|.||.:..
Human   411 GVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITT 475

  Fly   156 AAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSIIYFPLFATL-----NDLGP 215
            ..:::            |..:::|.|.||:|||..|..|||:.||.||||.:|.:     |:.|
Human   476 GPRVS------------ALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDG- 527

  Fly   216 RRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADGEKEFKGISDCITKTLKHE 280
            :.:.||       ..|||..||..||..|.|.||:|||||...:| |:..:.|:.||..|.|:.|
Human   528 QVSPGS-------LLLAGAIAGMPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREE 584

  Fly   281 GPTAFFKGGLCRMIVIAPLFGIAQTVYYL 309
            ||.|.:||...|:...:|.||:....|.|
Human   585 GPKALWKGAGARVFRSSPQFGVTLLTYEL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	41/78 (53%)
		Mito_carr	115..213	CDD:278578	38/102 (37%)
		Mito_carr	226..307	CDD:278578	33/80 (41%)
SLC25A13	XP_006715894.1	EF-hand_7	28..92	CDD:290234
		EFh	30..92	CDD:298682
		PTZ00168	338..601	CDD:185494	118/275 (43%)
		Mito_carr	340..433	CDD:278578	45/86 (52%)
		Mito_carr	435..522	CDD:278578	37/98 (38%)
		Mito_carr	527..622	CDD:278578	38/96 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940