DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC1 and slc25a13

DIOPT Version :9

Sequence 1:	NP_001262490.1	Gene:	GC1 / 41448	FlyBaseID:	FBgn0260743	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_031759029.1	Gene:	slc25a13 / 100124779	XenbaseID:	XB-GENE-1013331	Length:	743	Species:	Xenopus tropicalis

Alignment Length:	299	Identity:	129/299 - (43%)
Similarity:	176/299 - (58%)	Gaps:	34/299 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QFALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPN--GERMYNSMFDCFRKTYKAEGYFG 80
            :|||      |.|||.:|.|.|:|:||||||:|||:...:  ||.||.:.||||:|..:.||:||
Frog   398 RFAL------GSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFG 456

  Fly    81 MYRGSGVNILLITPEKAIKLTANDYFRHKLTTKDGKLPLTSQMVAGGLAGAFQIIVTTPMELLKI 145
            :|||....:|.:.||||||||.||:.|.|.||.:|.:||.::::|||.||..|:|.|.|:|::||
Frog   457 LYRGLLPQLLGVAPEKAIKLTVNDFVRDKFTTNEGSIPLLAEILAGGCAGGSQVIFTNPLEIVKI 521

  Fly   146 QMQDAGRVAAAAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSIIYFPLFATL 210
            ::|.||.:....:::..||            ::|.|.||||||..|..|||:.||.||||.:|.:
Frog   522 RLQVAGEITTGPRVSALTV------------LRDLGFFGLYKGAKACFLRDIPFSAIYFPCYAHM 574

  Fly   211 -----NDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADGEKEFKGIS 270
                 |:.| |.:.|       ...|||..||..||..|.|.||:|||||...:| |:..:.|:.
Frog   575 KASFANEDG-RVSPG-------YLLLAGAIAGMPAASLVTPADVIKTRLQVAARA-GQTTYTGVI 630

  Fly   271 DCITKTLKHEGPTAFFKGGLCRMIVIAPLFGIAQTVYYL 309
            ||..|.||.||..|.:||...|:...:|.||:....|.|
Frog   631 DCFRKILKEEGHRALWKGAGARVFRSSPQFGVTLVTYEL 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC1	NP_001262490.1	Mito_carr	36..113	CDD:278578	42/78 (54%)
		Mito_carr	115..213	CDD:278578	40/102 (39%)
		Mito_carr	226..307	CDD:278578	33/80 (41%)
slc25a13	XP_031759029.1	EF-hand_7	82..147	CDD:404394
		EFh_PEF	<120..253	CDD:355382
		Mito_carr	396..489	CDD:395101	50/96 (52%)
		Mito_carr	491..578	CDD:395101	39/98 (40%)
		Mito_carr	583..675	CDD:395101	38/96 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030