DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12213 and golim4b

DIOPT Version :9

Sequence 1:	NP_001097754.1	Gene:	CG12213 / 41447	FlyBaseID:	FBgn0260742	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001014371.2	Gene:	golim4b / 541535	ZFINID:	ZDB-GENE-050327-74	Length:	478	Species:	Danio rerio

Alignment Length:	543	Identity:	102/543 - (18%)
Similarity:	182/543 - (33%)	Gaps:	164/543 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RSGRVRICILMSMFI--VLIMMIVIYQMSQHQLDESRA-------FQEGLSVQMQ---------- 53
            |..|:....|:.:|:  .|...::.|:|.: :|.::.|       .||.||.|:|
Zfish     9 RQRRIFQSFLLVIFVCGTLCAFMISYEMHK-ELKKTEATALKYQQHQESLSAQLQVVYEHHSKLE 72

  Fly    54 --------------------------SLNAEKLTAEKRMSALRSEKMTLQEQYEGQLAEALQKQH 92
                                      :||.||..:..|:::|::|...||.|:|.     |:.|:
Zfish    73 KSLQKERLEHKKAEEDFLVFKRESQKALNKEKQDSTYRLNSLQTEHQILQSQHED-----LKMQY 132

  Fly    93 DTEHALQEKFDAQVEKYKLL----EIKYTNLEAE---FVKSKKKHIEDTNAFDQKLQKVLADLHK 150
               :.||||...|.:.::.:    .:|..||:.|   .:...|:::.:....:::|:|...|::.
Zfish   133 ---YELQEKHQNQGQDHERVLDEHRLKIDNLQREKEVEISRLKENVYNLREENRQLRKAHQDIYA 194

  Fly   151 ---DKASKEREVAAWKEKLDKLQRDGEHKIHALEATIAEFKTN-------------CNYVPKV-- 197
               |...:.:.:.|.|:.|.....|  ||...:.|.:..::.|             .|.|.||
Zfish   195 QLLDVQEQHKNLQASKDHLSLALED--HKNAVVAAQVEGYEGNGKGFSPRGVLEIENNNVTKVAM 257

  Fly   198 -QPAEAPV--QGHQQQLNKPAEQMPTT------HHSNPAQLAHSIEKPRNEKSFDAQVQVSEGLY 253
             ||.:..:  :|     |...|:..|:      .....|:|.||:..|..
Zfish   258 KQPRQIDIFAEG-----NGKKEERSTSKDRGGEDKGEKAELEHSLSNPEE--------------- 302

  Fly   254 RIGGGVNLLATNPKQNLTNASTNFTLKSNGDGTQEQPQLPLQPFAVSNNHSLILNSVENFQIVPK 318
                    |..||:..|:.:.              :.|...:|...:..|         |:.:
Zfish   303 --------LGINPRNTLSQSL--------------EKQTQTEPLHTTKAH---------FEAL-- 334

  Fly   319 SVSEKQQQEEPQLSGGPVSPLSAPRKSSTQASVGSASDKKAGDAPNASVAPKVSSSGLPPLAVPP 383
                     ||.|:|..|..|...........|..|..:..|...|..:.....:.       ..
Zfish   335 ---------EPVLAGNAVQTLLGMAGQDAAKHVEDAQKQGIGKNLNTEIEANNQNE-------EE 383

  Fly   384 AKTERKLPENVAPI-PENFED---KADTKGDAVDVDNAAEDLPKNENNNRYANAVNDMEGNKNVG 444
            .:.|.:...|...| ||..|.   ..:.:.|...||:..|:.......||...|..| |..:::.
Zfish   384 DEEETEYKTNADKIRPEEDEQLVVAGNPEPDEQYVDDVEEETLDESVLNRQKRAEED-ESEEDLY 447

  Fly   445 VAPKPIEDSGAHEVKDALNEPSF 467
            .....::|....|.:...|:..|
Zfish   448 TERDGVQDHANPESETFANQEYF 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12213	NP_001097754.1	CCDC158	<33..>213	CDD:292543	51/250 (20%)
golim4b	NP_001014371.2	GrpE	51..>202	CDD:295646	33/158 (21%)
golim4b	NP_001014371.2	P-loop_NTPase	<217..260	CDD:304359	9/44 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28XWM
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900