Protein Alignment aurA and RPS6KA5

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_004746.2
• Gene: RPS6KA5 / 9252
• HGNCID: 10434
• Length: 802
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 106/316 - (33%)
• Similarity: 167/316 - (52%)
• Gaps: 35/316 - (11%)

  Fly   119 ESSKELGAASSSAE-----------KEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAR 172
            |.....|||.:||:           |.:.:|.......:|. .:.||::.::||.|.:|.|:|.|
Human     4 EGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKV-GIENFELLKVLGTGAYGKVFLVR 67

  Fly   173 E---KESQFVVALKVLFKRQIGE--SNVEHQVRREIEIQSHLRH-PHILRLYAYFHDDVRIYLIL 231
            :   .::..:.|:|||.|..|.:  ...|| .|.|.::..|:|. |.::.|:..|..:.:::|||
Human    68 KISGHDTGKLYAMKVLKKATIVQKAKTTEH-TRTERQVLEHIRQSPFLVTLHYAFQTETKLHLIL 131

  Fly   232 EYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIA 296
            :|...|.||..|..:  :||.|.:...|:..:..||.:||:..||:||||.||:||...|.:.:.
Human   132 DYINGGELFTHLSQR--ERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLT 194

  Fly   297 DFGWS---VHEPNSMRMTLCGTVDYLPPEMVQG--KPHTKNVDLWSLGVLCFELLVGHAPFY--- 353
            |||.|   |.:......:.|||::|:.|::|:|  ..|.|.||.||||||.:|||.|.:||.
Human   195 DFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDG 259

  Fly   354 SKNYD-ETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRL-----PLDQVMVH 403
            .||.. |..::|||.:...|:.:|..|..||.:||:.:|:.||     ..|::..|
Human   260 EKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEH 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	97/271 (36%)
RPS6KA5	NP_004746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/18 (33%)
		STKc_MSK1_N	48..337	CDD:270764	97/271 (36%)
		S_TK_X	320..379	CDD:214529
		STKc_MSK1_C	418..727	CDD:271081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..802