Protein Alignment aurA and AURKB

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001271455.1
• Gene: AURKB / 9212
• HGNCID: 11390
• Length: 345
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 173/322 - (53%)
• Similarity: 232/322 - (72%)
• Gaps: 10/322 - (3%)

  Fly    95 APAPVAPIKKPESLSKQKPTAAS-----SESSKELGAASSSAEKEKTKTETQPQKPKKTWELNNF 154
            ||:.::.:  |:.:.:::|...|     |.|:.:..||......|.: :.|.....::.:.:::|
Human    17 APSGLSTL--PQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENS-SGTPDILTRRHFTIDDF 78

  Fly   155 DIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYA 219
            :|||.||:||||||||||||:|.|:||||||||.||.:..||||:|||||||:||.||:|||||.
Human    79 EIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 143

  Fly   220 YFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPEN 284
            ||:|..||||||||||:|.|:..||..  ..|||:::||.::.|..||:|.|.:.:|||||||||
Human   144 YFYDRRRIYLILEYAPRGELYKELQKS--CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPEN 206

  Fly   285 LLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGH 349
            ||||.||.|||||||||||.|:..|.|:|||:|||||||::|:.|.:.||||.:||||:|||||:
Human   207 LLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGN 271

  Fly   350 APFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ 411
            .||.|.:::|||::|:|||.|.|..:...|..||||||..||..||||.||..|||:.|:::
Human   272 PPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSR 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	161/253 (64%)
AURKB	NP_001271455.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		2/4 (50%)
		Protein Kinases, catalytic domain	71..340	CDD:473864	162/265 (61%)