Protein Alignment aurA and RPS6KA4

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_003933.1
• Gene: RPS6KA4 / 8986
• HGNCID: 10433
• Length: 772
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 95/304 - (31%)
• Similarity: 153/304 - (50%)
• Gaps: 39/304 - (12%)

  Fly   127 ASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLARE---KESQFVVALKVLFKR 188
            |:.:..:||...|             ||::.::||.|.:|.|:|.|:   .::..:.|:|||.|.
Human    19 ANLTGHEEKVSVE-------------NFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKA 70

  Fly   189 Q-IGESNVEHQVRREIEIQSHLRH-PHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRF 251
            . :..:..:...|.|..:...:|. |.::.|:..|..|.:::|||:|...|.:|..|..:  :.|
Human    71 ALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQR--QYF 133

  Fly   252 DERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWS---VHEPNSMRMTLC 313
            .|.:...|...:..||.:||:..||:||:|.||:||..:|.:.:.|||.|   :.|......:.|
Human   134 KEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFC 198

  Fly   314 GTVDYLPPEMVQGKP-HTKNVDLWSLGVLCFELLVGHAPFY---SKNYD-ETYKKILKVDYKLPE 373
            ||::|:.||:::.|. |.|.||.||||:|.||||.|.:||.   .:|.. |..::|||.....|.
Human   199 GTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPP 263

  Fly   374 HISKAASHLISKLLVLNPQHRL-----PLDQVMVHP------WI 406
            .|...|..|:.:||..:|:.||     ...:|..||      |:
Human   264 RIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWV 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	91/278 (33%)
RPS6KA4	NP_003933.1	STKc_MSK2_N	32..364	CDD:270765	91/278 (33%)
		Protein Kinases, catalytic domain	404..714	CDD:473864
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..696
		Required for nuclear targeting and association with MAPK14	725..772
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..772