DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurA and aurkb

DIOPT Version :9

Sequence 1:	NP_476749.1	Gene:	aurA / 41446	FlyBaseID:	FBgn0000147	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_997731.2	Gene:	aurkb / 791894	ZFINID:	ZDB-GENE-020419-40	Length:	320	Species:	Danio rerio

Alignment Length:	331	Identity:	168/331 - (50%)
Similarity:	227/331 - (68%)	Gaps:	34/331 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PSVKKTTSEFAAPAPVAPIK---KPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKP 145
            |.|::|.|     |.|.|::   .|::.:...|.....:|:
Zfish     9 PKVQQTPS-----AGVGPLRVEMNPDTHAVSGPGRVPVKSN------------------------ 44

  Fly   146 KKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLR 210
            .|...:::|||||.||:|||||||||||::.:.|:|||||||.|:.:..||||:|||||||||||
Zfish    45 SKVLSIDDFDIGRPLGKGKFGNVYLARERKLKVVIALKVLFKSQMVKEGVEHQLRREIEIQSHLR 109

  Fly   211 HPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDI 275
            ||:|||.|.|||||.|::|||||||:|.::..||.  ...||::::|||::.:..||.|.||:.:
Zfish   110 HPNILRFYNYFHDDTRVFLILEYAPRGEMYKELQR--YGHFDDQRTATYMEEVSDALQYCHEKKV 172

  Fly   276 IHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGV 340
            |||||||||||||::|.|||||||||||.|:..|.|:|||:|||||||::|..|.:.|||||:||
Zfish   173 IHRDIKPENLLLGYRGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGHSHDEKVDLWSIGV 237

  Fly   341 LCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPW 405
            ||:|.|||:.||.:.::.||||:|.|||.:.|:.:|:.|..||||||..:|..||||..||.|||
Zfish   238 LCYECLVGNPPFETASHAETYKRITKVDLQFPKLVSEGARDLISKLLRHSPSMRLPLRSVMEHPW 302

  Fly   406 ILAHTQ 411
            :.|:::
Zfish   303 VKANSR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	156/253 (62%)
aurA	NP_476749.1	S_TKc	154..406	CDD:214567	155/251 (62%)
aurkb	NP_997731.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		9/33 (27%)
		STKc_Aurora-B_like	46..315	CDD:271019	158/265 (60%)
		S_TKc	53..303	CDD:214567	155/251 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1052
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2104
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm25953
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900