DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurA and AURKC

DIOPT Version :9

Sequence 1:	NP_476749.1	Gene:	aurA / 41446	FlyBaseID:	FBgn0000147	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001015878.1	Gene:	AURKC / 6795	HGNCID:	11391	Length:	309	Species:	Homo sapiens

Alignment Length:	299	Identity:	166/299 - (55%)
Similarity:	222/299 - (74%)	Gaps:	5/299 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 ASSESSKELGAASSSAEKEKTKTET--QPQKP-KKTWELNNFDIGRLLGRGKFGNVYLAREKESQ 177
            :|..:..:||.|..:.|:..|..:|  ||..| .:...:::|:|||.||:||||||||||.|||.
Human     2 SSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESH 66

  Fly   178 FVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNA 242
            |:||||||||.||.:..:|||:|||||||:||:||:|||||.||||..|:||||||||:|.|:..
Human    67 FIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKE 131

  Fly   243 LQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNS 307
            ||..  ::.||:::||.|:.|..||.|.|::.:|||||||||||||.:|.:||||||||||.|:.
Human   132 LQKS--EKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL 194

  Fly   308 MRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLP 372
            .|.|:|||:|||||||::|:.:.:.||||.:||||:|||||:.||.|.::.|||::|||||.:.|
Human   195 RRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 259

  Fly   373 EHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ 411
            ..:...|..|||:||...|..||||.|::.|||:.||::
Human   260 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSR 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	154/253 (61%)
aurA	NP_476749.1	S_TKc	154..406	CDD:214567	153/251 (61%)
AURKC	NP_001015878.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/30 (30%)
		STKc_Aurora-B_like	36..305	CDD:271019	156/265 (59%)
		S_TKc	43..293	CDD:214567	153/251 (61%)
		Interaction with BIRC5. /evidence=ECO:0000269\|PubMed:27332895	292..309		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1120
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2178
Isobase	1	0.950	-	0	Normalized mean entropy	S591
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm40694
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.950