Protein Alignment aurA and RPS6KB2

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_003943.2
• Gene: RPS6KB2 / 6199
• HGNCID: 10437
• Length: 482
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 102/325 - (31%)
• Similarity: 162/325 - (49%)
• Gaps: 31/325 - (9%)

  Fly   108 LSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWELNN--------------FDIGR 158
            |..:....:..|...||..|.:....|......:|....:..||..              |::.|
Human     7 LDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLR 71

  Fly   159 LLGRGKFGNVYLAREKESQ---FVVALKVLFKRQI--GESNVEHQVRREIEIQSHLRHPHILRLY 218
            :||:|.:|.|:..|:.:..   .:.|:|||.|.:|  ...:..| .|.|..|...::||.|:.|.
Human    72 VLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAH-TRAERNILESVKHPFIVELA 135

  Fly   219 AYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPE 283
            ..|....::|||||....|.||..|:.:.:  |.|..:..|:..:..||.:||.:.||:||:|||
Human   136 YAFQTGGKLYLILECLSGGELFTHLEREGI--FLEDTACFYLAEITLALGHLHSQGIIYRDLKPE 198

  Fly   284 NLLLGHKGVLKIADFGW---SVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFEL 345
            |::|..:|.:|:.|||.   |:|| .::..|.|||::|:.||::....|.:.||.||||.|.:::
Human   199 NIMLSSQGHIKLTDFGLCKESIHE-GAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDM 262

  Fly   346 LVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRL---PLD--QVMVHPW 405
            |.|..||.::|..:|..||::....||.:::..|..|:.|.|..||..|:   |.|  .|..||:
Human   263 LTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPF 327

  Fly   406  405
            Human   328  327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	93/280 (33%)
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		4/18 (22%)
		STKc_p70S6K	70..392	CDD:270736	92/262 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..482
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:12529391	471..477