Protein Alignment aurA and PRKACB

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_891993.1
• Gene: PRKACB / 5567
• HGNCID: 9381
• Length: 398
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 96/306 - (31%)
• Similarity: 161/306 - (52%)
• Gaps: 15/306 - (4%)

  Fly   106 ESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYL 170
            :||...:.||....|.||..|.:.....:|.:..||     ....|.:|:..:.||.|.||.|.|
Human    48 DSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQ-----NNAGLEDFERKKTLGTGSFGRVML 107

  Fly   171 AREKESQFVVALKVLFKRQIGE-SNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYA 234
            .:.|.::...|:|:|.|:::.: ..:||.:..:..:|: :..|.::||...|.|:..:|:::||.
Human   108 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-VNFPFLVRLEYAFKDNSNLYMVMEYV 171

  Fly   235 PQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFG 299
            |.|.:|:.|:.  :.||.|..:..|...:.....|||..|:|:||:||||||:.|:|.:::.|||
Human   172 PGGEMFSHLRR--IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFG 234

  Fly   300 WSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKI 364
            :: ........|||||.:||.||::..|.:.|.||.|:||||.:|:..|:.||::....:.|:||
Human   235 FA-KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 298

  Fly   365 LKVDYKLPEHISKAASHLISKLLVLNPQHRL-----PLDQVMVHPW 405
            :....:.|.|.|.....|:..||.::...|.     .:..:..|.|
Human   299 VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKW 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	84/259 (32%)
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	84/260 (32%)