Protein Alignment aurA and PRKACA

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 111/382 - (29%)
• Similarity: 182/382 - (47%)
• Gaps: 57/382 - (14%)

  Fly    35 LGKKPNSENMAPASKPLPGSSGALIRKPGL--GGSNSIASSEGNNF---QKPMVPSVKKTTSEFA 94
            ||.|..:|  .|.....|...| |..:|||  .|:...|.|:|..:   ::|...:|.|   ||.
Human    38 LGAKVTAE--PPKGTCYPSPRG-LHPRPGLPREGARGTAKSQGYKYLGWRRPWPWNVVK---EFL 96

  Fly    95 APAPVAPIKKPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRL 159
            |.|....:||.||                                    ..:.|..|:.|:..:.
Human    97 AKAKEDFLKKWES------------------------------------PAQNTAHLDQFERIKT 125

  Fly   160 LGRGKFGNVYLAREKESQFVVALKVLFKRQIGE-SNVEHQVRREIEIQSHLRHPHILRLYAYFHD 223
            ||.|.||.|.|.:.||:....|:|:|.|:::.: ..:||.:..:..:|: :..|.:::|...|.|
Human   126 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQA-VNFPFLVKLEFSFKD 189

  Fly   224 DVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLG 288
            :..:|:::||.|.|.:|:.|:.  :.||.|..:..|...:.....|||..|:|:||:||||||:.
Human   190 NSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 252

  Fly   289 HKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFY 353
            .:|.:::.|||:: ........|||||.:||.||::..|.:.|.||.|:||||.:|:..|:.||:
Human   253 QQGYIQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 316

  Fly   354 SKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRL-----PLDQVMVHPW 405
            :....:.|:||:....:.|.|.|.....|:..||.::...|.     .::.:..|.|
Human   317 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	83/259 (32%)
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	83/260 (32%)