Protein Alignment aurA and PDPK1

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: XP_011520823.1
• Gene: PDPK1 / 5170
• HGNCID: 8816
• Length: 590
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 119/344 - (34%)
• Similarity: 173/344 - (50%)
• Gaps: 32/344 - (9%)

  Fly    84 PSVKKTTSEFAAPAPVAPIKKPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKT 148
            ||:.:|.:|.:.| |..|     ..|:|.|....:.:....||.|..      ..:..||..||.
Human    60 PSMVRTQTESSTP-PGIP-----GGSRQGPAMDGTAAEPRPGAGSLQ------HAQPPPQPRKKR 112

  Fly   149 WELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPH 213
            .|  :|..|::||.|.|..|.||||..:....|:|:|.||.|.:.|....|.||.::.|.|.||.
Human   113 PE--DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 175

  Fly   214 ILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHR 278
            .::||..|.||.::|..|.||..|.|...:  :.:..|||..:..|...:.|||.|||.:.||||
Human   176 FVKLYFTFQDDEKLYFGLSYAKNGELLKYI--RKIGSFDETCTRFYTAEIVSALEYLHGKGIIHR 238

  Fly   279 DIKPENLLLGHKGVLKIADFGWS-VHEPNSMRM---TLCGTVDYLPPEMVQGKPHTKNVDLWSLG 339
            |:||||:||.....::|.|||.: |..|.|.:.   :..||..|:.||::..|...|:.|||:||
Human   239 DLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALG 303

  Fly   340 VLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQ----- 399
            .:.::|:.|..||.:.|....::||:|::|..||.....|..|:.|||||:...||..::
Human   304 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG 368

  Fly   400 -VMVHP------WILAHTQ 411
             :..||      |...|.|
Human   369 PLKAHPFFESVTWENLHQQ 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	99/269 (37%)
PDPK1	XP_011520823.1	STKc_PDK1	114..376	CDD:270733	99/265 (37%)
		PH_PDK1	475..581	CDD:241293