Protein Alignment aurA and Aurka

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_695208.2
• Gene: Aurka / 261730
• RGDID: 628895
• Length: 397
• Species: Rattus norvegicus
• Alignment Length: 421
• Identity: 193/421 - (45%)
• Similarity: 256/421 - (60%)
• Gaps: 63/421 - (14%)

  Fly    10 RPKENAPHRMPEKSAAVHNMQKNLLLGKKP-------------------NSENMAP-ASKPLPGS 54
            |.|||...| |.||......::.|:..:.|                   ||:.:.| |.||:.|.
  Rat     3 RCKENCVSR-PVKSTVPFGPKRVLVTEQIPSQHPGSASSGQAQRVLCPSNSQRVPPQAQKPVAGQ 66

  Fly    55 SGALIRKPGLGGSNSIASSEGNNFQKPMVPSVKKTTSEFAAPAPVAPIKKPESLSKQKPTAASSE 119
            ...|.:.|...|                             |.|.:.:..|:...:.:|.|:.:.
  Rat    67 KPVLKQLPAASG-----------------------------PRPASRLSNPQKSEQPQPAASGNN 102

  Fly   120 SSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKV 184
            |           |||:|..:......|:.|.|.:|||||.||:||||||||||||:|:|::||||
  Rat   103 S-----------EKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKV 156

  Fly   185 LFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMK 249
            |||.|:.::.||||:|||:|||||||||:|||||.||||..|:||||||||.||::..|  |.:.
  Rat   157 LFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLS 219

  Fly   250 RFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCG 314
            :|||:::||||..|.:||.|.|.:.:|||||||||||||..|.|||||||||||.|:|.|.||||
  Rat   220 KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCG 284

  Fly   315 TVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAA 379
            |:|||||||::|:.|.:.||||||||||:|.|||..||.:..|.|||::|.:|::..|:.:::.|
  Rat   285 TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGA 349

  Fly   380 SHLISKLLVLNPQHRLPLDQVMVHPWILAHT 410
            ..|||:||..|...||.|.:|:.||||.|::
  Rat   350 RDLISRLLKHNSSQRLTLAEVLEHPWIKANS 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	158/253 (62%)
Aurka	NP_695208.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118		30/155 (19%)
		STKc_Aurora-A	120..376	CDD:271018	159/257 (62%)
		Activation segment. /evidence=ECO:0000250|UniProtKB:O14965	273..286		8/12 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..397		1/3 (33%)