DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurA and Aurka

DIOPT Version :9

Sequence 1:	NP_476749.1	Gene:	aurA / 41446	FlyBaseID:	FBgn0000147	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_695208.2	Gene:	Aurka / 261730	RGDID:	628895	Length:	397	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	193/421 - (45%)
Similarity:	256/421 - (60%)	Gaps:	63/421 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RPKENAPHRMPEKSAAVHNMQKNLLLGKKP-------------------NSENMAP-ASKPLPGS 54
            |.|||...| |.||......::.|:..:.|                   ||:.:.| |.||:.|.
  Rat     3 RCKENCVSR-PVKSTVPFGPKRVLVTEQIPSQHPGSASSGQAQRVLCPSNSQRVPPQAQKPVAGQ 66

  Fly    55 SGALIRKPGLGGSNSIASSEGNNFQKPMVPSVKKTTSEFAAPAPVAPIKKPESLSKQKPTAASSE 119
            ...|.:.|...|                             |.|.:.:..|:...:.:|.|:.:.
  Rat    67 KPVLKQLPAASG-----------------------------PRPASRLSNPQKSEQPQPAASGNN 102

  Fly   120 SSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKV 184
            |           |||:|..:......|:.|.|.:|||||.||:||||||||||||:|:|::||||
  Rat   103 S-----------EKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKV 156

  Fly   185 LFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMK 249
            |||.|:.::.||||:|||:|||||||||:|||||.||||..|:||||||||.||::..|  |.:.
  Rat   157 LFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLS 219

  Fly   250 RFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCG 314
            :|||:::||||..|.:||.|.|.:.:|||||||||||||..|.|||||||||||.|:|.|.||||
  Rat   220 KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCG 284

  Fly   315 TVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAA 379
            |:|||||||::|:.|.:.||||||||||:|.|||..||.:..|.|||::|.:|::..|:.:::.|
  Rat   285 TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGA 349

  Fly   380 SHLISKLLVLNPQHRLPLDQVMVHPWILAHT 410
            ..|||:||..|...||.|.:|:.||||.|::
  Rat   350 RDLISRLLKHNSSQRLTLAEVLEHPWIKANS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	158/253 (62%)
aurA	NP_476749.1	S_TKc	154..406	CDD:214567	157/251 (63%)
Aurka	NP_695208.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		30/155 (19%)
		STKc_Aurora-A	120..376	CDD:271018	159/257 (62%)
		Activation segment. /evidence=ECO:0000250\|UniProtKB:O14965	273..286		8/12 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..397		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339349
Domainoid	1	1.000	331	1.000	Domainoid score	I1109
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2670
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2120
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm44830
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800