DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurA and Aurkb

DIOPT Version :9

Sequence 1:	NP_476749.1	Gene:	aurA / 41446	FlyBaseID:	FBgn0000147	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_035626.1	Gene:	Aurkb / 20877	MGIID:	107168	Length:	345	Species:	Mus musculus

Alignment Length:	368	Identity:	179/368 - (48%)
Similarity:	241/368 - (65%)	Gaps:	31/368 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 MAPASKPLPGSSGALIRKPGLGGSNSIASSEGNNFQKPMVPSVKKTTSEFAAPAPVAPIKKPESL 108
            ||......|...|:...:.||           |...:.::.....|||..|.      :.:..|.
Mouse     1 MAQKENAYPWPYGSKTSQSGL-----------NTLSQRVLRKEPATTSALAL------VNRFNSQ 48

  Fly   109 SKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLARE 173
            |    |||..:...|        .|.:..|.:|..:.|:.:.::||:|||.||:|||||||||||
Mouse    49 S----TAAPGQKLAE--------NKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLARE 101

  Fly   174 KESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGT 238
            |:|:|:||||:|||.||.:..||||:|||||||:||:||:||:||.||:|..||||||||||:|.
Mouse   102 KKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGE 166

  Fly   239 LFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVH 303
            |:..||..  :.|||:::||.::.|..||.|.|::.:|||||||||||||.:|.|||||||||||
Mouse   167 LYKELQKS--RTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVH 229

  Fly   304 EPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVD 368
            .|:..|.|:|||:|||||||::|:.|.:.||||.:||||:||:||:.||.|.::.|||::|:|||
Mouse   230 APSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVD 294

  Fly   369 YKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ 411
            .|.|..:...|..||||||..||..||||.:|..|||:.|:::
Mouse   295 LKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRANSR 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	157/253 (62%)
aurA	NP_476749.1	S_TKc	154..406	CDD:214567	155/251 (62%)
Aurkb	NP_035626.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..77		8/34 (24%)
		PKc_like	77..344	CDD:304357	158/263 (60%)
		S_TKc	82..332	CDD:214567	155/251 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I1123
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2166
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm42768
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860