Protein Alignment aurA and Aurkb

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_446201.1
• Gene: Aurkb / 114592
• RGDID: 621625
• Length: 343
• Species: Rattus norvegicus
• Alignment Length: 313
• Identity: 166/313 - (53%)
• Similarity: 230/313 - (73%)
• Gaps: 8/313 - (2%)

  Fly   105 PESLSKQKPTAASSESSKELGAASSSA------EKEKTKTETQPQKPKKTWELNNFDIGRLLGRG 163
            |:.:.:::|....:::......:.|:|      .:.|..|..|..:.::.:.::||:|||.||:|
  Rat    25 PQRVLRKEPAVTPAQALMNRSNSQSTAVPGQKLTENKGATALQGSQSRQPFTIDNFEIGRPLGKG 89

  Fly   164 KFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIY 228
            |||||||||||:|:|:||||:|||.||.:..||||:|||||||:||:||:||:||.||:|..|||
  Rat    90 KFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIY 154

  Fly   229 LILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVL 293
            |||||||:|.|:..||..  ..|||:::||.::.|..||:|.|::.:|||||||||||||.:|.|
  Rat   155 LILEYAPRGELYKELQKS--GTFDEQRTATIMEELSDALMYCHKKKVIHRDIKPENLLLGLQGEL 217

  Fly   294 KIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYD 358
            ||||||||||.|:..|.|:|||:|||||||::|:.|.:.||||.:||||:||:||:.||.|.::.
  Rat   218 KIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHS 282

  Fly   359 ETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ 411
            |||::|:|||.|.|..:...|..||||||..||..||||:||..|||:.|:::
  Rat   283 ETYRRIVKVDLKFPSSMPLGAKDLISKLLKHNPSQRLPLEQVSAHPWVRANSR 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	158/253 (62%)
Aurkb	NP_446201.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..57		2/20 (10%)
		STKc_Aurora-B_like	75..342	CDD:271019	159/263 (60%)