DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurA and Aurkb

DIOPT Version :9

Sequence 1:	NP_476749.1	Gene:	aurA / 41446	FlyBaseID:	FBgn0000147	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_446201.1	Gene:	Aurkb / 114592	RGDID:	621625	Length:	343	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	166/313 - (53%)
Similarity:	230/313 - (73%)	Gaps:	8/313 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 PESLSKQKPTAASSESSKELGAASSSA------EKEKTKTETQPQKPKKTWELNNFDIGRLLGRG 163
            |:.:.:::|....:::......:.|:|      .:.|..|..|..:.::.:.::||:|||.||:|
  Rat    25 PQRVLRKEPAVTPAQALMNRSNSQSTAVPGQKLTENKGATALQGSQSRQPFTIDNFEIGRPLGKG 89

  Fly   164 KFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIY 228
            |||||||||||:|:|:||||:|||.||.:..||||:|||||||:||:||:||:||.||:|..|||
  Rat    90 KFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIY 154

  Fly   229 LILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVL 293
            |||||||:|.|:..||..  ..|||:::||.::.|..||:|.|::.:|||||||||||||.:|.|
  Rat   155 LILEYAPRGELYKELQKS--GTFDEQRTATIMEELSDALMYCHKKKVIHRDIKPENLLLGLQGEL 217

  Fly   294 KIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYD 358
            ||||||||||.|:..|.|:|||:|||||||::|:.|.:.||||.:||||:||:||:.||.|.::.
  Rat   218 KIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHS 282

  Fly   359 ETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ 411
            |||::|:|||.|.|..:...|..||||||..||..||||:||..|||:.|:::
  Rat   283 ETYRRIVKVDLKFPSSMPLGAKDLISKLLKHNPSQRLPLEQVSAHPWVRANSR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	158/253 (62%)
aurA	NP_476749.1	S_TKc	154..406	CDD:214567	156/251 (62%)
Aurkb	NP_446201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57		2/20 (10%)
		STKc_Aurora-B_like	75..342	CDD:271019	159/263 (60%)
		S_TKc	80..330	CDD:214567	156/251 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I1109
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2120
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm44830
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830