Protein Alignment CG3281 and ZNF439

DIOPT Version :10

• Sequence 1: NP_650132.1
• Gene: CG3281 / 41445
• FlyBaseID: FBgn0260741
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001335647.1
• Gene: ZNF439 / 90594
• HGNCID: 20873
• Length: 507
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 127/576 - (22%)
• Similarity: 202/576 - (35%)
• Gaps: 173/576 - (30%)

  Fly     5 EIHVNISSQTCRVCLETHETNLYVHDEIKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCA 69
            ::.||.:.:...: |:..:.||       |.::.||.:..|.::.|   .|.|.|:
Human    31 DVAVNFTQEEWAL-LDISQKNL-------YREVMLETFWNLTSIGK---KWKDQNI--------- 75

  Fly    70 RRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHV 134
                 .||:    :|.....:::.|::....|.|....:....:..|.:         :|.::..
Human    76 -----EYEY----QNPRRNFRSVTEEKVNEIKEDSHCGETFTPVPDDRL---------NFQKKKA 122

  Fly   135 EMEEKYGDQDCSAFTSDVG----EEPLYASEDRDDEPEDSFQLKPRPDEIENRELS---RPSQLG 192
            ..|.|    .|.:|..:||    ...:....|...:..:..:..|:|.:.:..:.:   .||...
Human   123 SPEVK----SCDSFVCEVGLGNSSSNMNIRGDTGHKACECQEYGPKPWKSQQPKKAFRYHPSLRT 183

  Fly   193 SRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFK 257
            ...:|:....|.|..|.:......|:.||. ..|.               |.|...|:.|.:
Human   184 QERDHTGKKPYACKECGKNIIYHSSIQRHM-VVHS---------------GDGPYKCKFCGK--- 229

  Fly   258 RQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSSL-TIHIRRHTGDNPY 321
                      |||..::.|..|.|....      |..:|..||.||..|:. .||.|.|.|:.||
Human   230 ----------AFHCLSLYLIHERTHTGE------KPYECKQCGKSFSYSATHRIHERTHIGEKPY 278

  Fly   322 KCDQCEKAF--PRS--------------------------------------------------- 333
            :|.:|.|||  |||
Human   279 ECQECGKAFHSPRSCHRHERSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKAL 343

  Fly   334 ---QDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIH 395
               .....|:|.|:||||.|||.|.|.|.|.....||.:.|:|::||.||.|.|:|.:|...:.|
Human   344 SSLTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYH 408

  Fly   396 MRRHTGERPYQCGVCGESFVCGSHLNIH-RNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSE 459
            .|.||||:||:|..||::|....:|.:| |...|.                .|| ..:...:...
Human   409 ERTHTGEKPYECKQCGKAFRSAPNLQLHGRTHTGE----------------KPY-QCKECGKAFR 456

  Fly   460 DIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSH 515
            ...::|:.|        |:....||      |:|..|.:.|:.......|....:|
Human   457 SASQLRIHR--------RIHTGEKP------YECKKCGKAFRYVQNFRFHERTQTH 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	15..91	CDD:214871	14/75 (19%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	2/16 (13%)
		COG5048	<294..>391	CDD:227381	47/153 (31%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	10/75 (13%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:463886	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:463886	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	6/17 (35%)
ZNF439	NP_001335647.1	KRAB	26..67	CDD:460171	9/43 (21%)
		C2H2 Zn finger	196..216	CDD:275368	5/20 (25%)
		COG5048	<204..381	CDD:227381	51/211 (24%)
		C2H2 Zn finger	224..244	CDD:275368	7/32 (22%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		C2H2 Zn finger	280..300	CDD:275368	8/19 (42%)
		C2H2 Zn finger	308..328	CDD:275368	0/19 (0%)
		COG5048	<321..492	CDD:227381	53/201 (26%)
		C2H2 Zn finger	336..356	CDD:275368	2/19 (11%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	3/27 (11%)
		C2H2 Zn finger	476..495	CDD:275368	4/18 (22%)