DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF616

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	548	Identity:	137/548 - (25%)
Similarity:	206/548 - (37%)	Gaps:	144/548 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IHVNISSQTCRVCLETHETNLY-VHDEIKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCA 69
            :|....|..|.||.:....|.| |..:..:...|                       .::|..|.
Human   234 VHTRGKSYQCDVCGKIFRKNSYFVRHQRSHTGQK-----------------------PYICNECG 275

  Fly    70 RRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQ-H 133
            :.                     |.:..        |:.|.:.|...:..........||::: |
Human   276 KS---------------------FSKSS--------HLAVHQRIHTGEKPYKCNLCGKSFSQRVH 311

  Fly   134 VEMEEKYGDQDCSAFTSDVGEEPLYASEDRDDEPEDS----FQL-----KPRPDEIENRELSRPS 189
            :.:.:          |...||.|...:|........|    .|:     ||...::..:.....|
Human   312 LRLHQ----------TVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRS 366

  Fly   190 QL-GSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCP 253
            .| ..|..||....|||..|.:||:|..||..| .:.|.:          .:.|     .|..|.
Human   367 NLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVH-RRIHTV----------EKPC-----KCNECG 415

  Fly   254 RTFKRQDTLRRHMQAFHP-----------------DAIALEPEETTDNSARKRIAKRRDCPHCGL 301
            :.|.::.:|..| |..|.                 ..:|:.....|...|.|       |..||.
Human   416 KVFSKRSSLAVH-QRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYK-------CNECGK 472

  Fly   302 SFPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLA 365
            .|.: |.|..|.|.|||:.||||::|.|.|.:...|::|.|.||||:|.:||.|.|.|..::..|
Human   473 VFSIHSRLAAHQRIHTGEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFA 537

  Fly   366 RHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHL----NIHRNR 426
            ||.|:|||::||.||.|.|.|.|.:.|.:|.|.|:||:||:|..||:.:...|||    .:|...
Human   538 RHRRIHTGEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHTGE 602

  Fly   427 KGHLI-----AVIPGNEV----EANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLP 482
            |.:..     |...|:.:    ..:....||   :.||..:...:|:.|      :|.|.:....
Human   603 KPYKCHECGKAFNQGSTLNRHQRIHTGEKPY---KCNQCGNSFSQRVHL------RLHQTVHTGD 658

  Fly   483 KPDVPAMCYKCGVCEQKFKSGALLTVHR 510
            :|      |||..|.:.||..:.||.|:
Human   659 RP------YKCNECGKTFKRSSNLTAHQ 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	9/78 (12%)
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	46/97 (47%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	12/22 (55%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		zf-H2C2_2	364..388	CDD:290200	14/23 (61%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	11/24 (46%)
		C2H2 Zn finger	407..424	CDD:275368	6/20 (30%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129
		C2H2 Zn finger	187..207	CDD:275368
		zf-H2C2_2	199..224	CDD:290200
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		COG5048	266..707	CDD:227381	129/516 (25%)
		C2H2 Zn finger	271..291	CDD:275368	5/48 (10%)
		zf-H2C2_2	283..308	CDD:290200	5/24 (21%)
		C2H2 Zn finger	299..319	CDD:275368	4/29 (14%)
		zf-H2C2_2	311..336	CDD:290200	6/34 (18%)
		C2H2 Zn finger	327..347	CDD:275368	3/19 (16%)
		C2H2 Zn finger	355..375	CDD:275368	3/19 (16%)
		C2H2 Zn finger	383..403	CDD:275368	8/20 (40%)
		C2H2 Zn finger	411..431	CDD:275368	6/20 (30%)
		C2H2 Zn finger	439..459	CDD:275368	1/19 (5%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..504	CDD:290200	13/23 (57%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		zf-H2C2_2	508..531	CDD:290200	12/22 (55%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	538..560	CDD:290200	13/21 (62%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..616	CDD:290200	5/24 (21%)
		C2H2 Zn finger	607..627	CDD:275368	2/19 (11%)
		zf-H2C2_2	620..644	CDD:290200	4/26 (15%)
		C2H2 Zn finger	635..655	CDD:275368	6/25 (24%)
		zf-H2C2_2	647..672	CDD:290200	9/36 (25%)
		C2H2 Zn finger	663..683	CDD:275368	7/18 (39%)
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000