DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF559

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	555	Identity:	149/555 - (26%)
Similarity:	210/555 - (37%)	Gaps:	141/555 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LETHETNLYVHDEIKYNDLKLELWQLLEAV---SKLKWTWTDPNLPMHLCQNCARRLIGAYEFIV 80
            |:..:.||       |.|:.||.::.|.||   |.:...|:.|.      ||.   |.|....:|
Human    95 LDQTQRNL-------YRDVMLENYKNLVAVDWESHINTKWSAPQ------QNF---LQGKTSSVV 143

  Fly    81 EVENAH--ETLQNLFEQQEVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQ 143
            |:|..|  |.|.: |.|.|.|.....               .:..:..|.|.::..|..:
Human   144 EMERNHFGEELFD-FNQCEKALSEHS---------------CLKTHRRTYFRKKTCECNQ----- 187

  Fly   144 DC-------SAFT----SDVGEEPLYASEDRDDEPEDSFQLKPRPDEIEN----------RELSR 187
             |       |.||    :|:|||                  .|..::.|.          ::.|:
Human   188 -CEKAFRKPSIFTLHKKTDIGEE------------------LPNCNQCETAFSQHLHLVCKKTSQ 233

  Fly   188 PSQLGSRLNHSANFIYKCAVCPRVFAKSESLTR------------HFSQAHKLTADVAAMKLANE 240
            ...|..:..|:....|||:.|.:....|..|..            |.......:...|.......
Human   234 NLHLVCKKTHTQEKPYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQT 298

  Fly   241 SCGTGLLTCEHCPRTFKRQDTLRRHMQAF-------HP---DAIALEPEETTDNSARKRIAKRRD 295
            ..|.....|:.|.:.|.....|.:|::..       |.   .|.|..|:.......|.| .|...
Human   299 QDGEKFYECKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTR-GKHYV 362

  Fly   296 CPHCGLSFP-VSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFI 359
            |..||..|. .|.|.||||.|||:.||:|::|.|||..|..|..|.|.||||:|.|||.|.|.|.
Human   363 CNECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFA 427

  Fly   360 SQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHR 424
            :.:.|..|||.|||::||.||.|.|:|:.|:..|.||:.|.|.:||.|..||::|:
Human   428 NSSHLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFI--------- 483

  Fly   425 NRKGHLIAVIPGNEVEANFAADPYVNA-RVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPA 488
             |...||..:..:..|..|..:....| |.:...|:               .:|:....:|
Human   484 -RSSFLIRHLRSHSAERPFECEECGKAFRYSSHLSQ---------------HKRIHTGERP---- 528

  Fly   489 MCYKCGVCEQKFKSGALLTVHRNKMSHYEIERVYE 523
              |||..|.|.|...:.||||   |..:..||.:|
Human   529 --YKCQKCGQAFSISSGLTVH---MRTHTGERPFE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	23/77 (30%)
		C2H2 Zn finger	205..226	CDD:275368	5/32 (16%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	50/97 (52%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	13/22 (59%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	13/22 (59%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		zf-H2C2_2	364..388	CDD:290200	14/23 (61%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	11/24 (46%)
		C2H2 Zn finger	407..424	CDD:275368	4/16 (25%)
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630	9/29 (31%)
		KRAB	78..117	CDD:279668	8/28 (29%)
		C2H2 Zn finger	158..177	CDD:275368	3/33 (9%)
		C2H2 Zn finger	185..240	CDD:275368	12/78 (15%)
		COG5048	212..601	CDD:227381	110/382 (29%)
		C2H2 Zn finger	213..243	CDD:275368	3/29 (10%)
		C2H2 Zn finger	251..299	CDD:275368	6/47 (13%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		zf-H2C2_2	376..399	CDD:290200	14/22 (64%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	404..428	CDD:290200	14/23 (61%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		zf-H2C2_2	431..454	CDD:290200	13/22 (59%)
		zf-C2H2	445..467	CDD:278523	10/21 (48%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	7/29 (24%)
		zf-H2C2_2	488..512	CDD:290200	5/23 (22%)
		C2H2 Zn finger	503..523	CDD:275368	4/34 (12%)
		zf-H2C2_2	515..539	CDD:290200	8/44 (18%)
		C2H2 Zn finger	531..551	CDD:275368	9/22 (41%)
		zf-H2C2_2	544..568	CDD:290200	8/18 (44%)
		C2H2 Zn finger	559..579	CDD:275368	149/555 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840