DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Mynn

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_085034.2	Gene:	Mynn / 80732	MGIID:	1931415	Length:	610	Species:	Mus musculus

Alignment Length:	325	Identity:	99/325 - (30%)
Similarity:	148/325 - (45%)	Gaps:	69/325 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 PDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRH------------------FS 223
            |.|:||    ...:|.:|.:.:...   |..|.:||:::.||.||                  |:
Mouse   283 PYELEN----AGEELDARFSKAKPM---CNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFT 340

  Fly   224 QAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARK 288
            |.::|...|      ....|.....||.|.:.|.::..|..|.:..|.:
Mouse   341 QCNQLKTHV------RTHTGERPYKCELCDKGFAQKCQLVFHSRMHHGE---------------- 383

  Fly   289 RIAKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECK 352
              .|...|..|.|.|..|| |.||.|:|:|:.||.||:|.:.|.::..|:.|:|:||||:|..|.
Mouse   384 --EKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCD 446

  Fly   353 ICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCG 417
            .|.|.|...:.|..|.|.|||::||.|.:|.|||:.|.:|..|.|.||||||:.|.:||.|:.
Mouse   447 TCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYT-- 509

  Fly   418 SHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLP 482
               :| :|.|.|...|..|.:...:.:.|.:.   |:::.|       :||.|   |.:.|:..|
Mouse   510 ---DI-KNLKKHKTKVHSGTDKNPDCSVDDHA---VSEQDS-------VQRSP---LSETLDVKP 557

Fly 483 482
Mouse 558 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	10/38 (26%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	44/97 (45%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	12/23 (52%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
Mynn	NP_085034.2	BTB	14..115	CDD:279045
		BTB	25..118	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..199
		Nuclear localization signal. /evidence=ECO:0000255	174..190
		Nuclear localization signal. /evidence=ECO:0000255	257..262
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-C2H2	304..324	CDD:278523	8/19 (42%)
		zf-H2C2_2	316..341	CDD:290200	5/24 (21%)
		C2H2 Zn finger	332..352	CDD:275368	4/25 (16%)
		zf-H2C2_2	345..369	CDD:290200	7/29 (24%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	10/19 (53%)
		zf-H2C2_2	401..426	CDD:290200	12/24 (50%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
		zf-H2C2_2	430..453	CDD:290200	11/22 (50%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		zf-H2C2_2	457..482	CDD:290200	13/24 (54%)
		C2H2 Zn finger	473..493	CDD:275368	9/19 (47%)
		C2H2 Zn finger	501..522	CDD:275368	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..548		7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910