DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF556

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_079243.1	Gene:	ZNF556 / 80032	HGNCID:	25669	Length:	456	Species:	Homo sapiens

Alignment Length:	503	Identity:	128/503 - (25%)
Similarity:	201/503 - (39%)	Gaps:	145/503 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAA 100
            |..||.|.||                     |.|:|.:  |..::     .||.::|      |:
Human    12 DFTLEEWALL---------------------NPAQRKL--YRDVM-----LETFKHL------AS 42

  Fly   101 KPDEVHVDVVELIDQDDV----VSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVG---EEPLY 158
            ..:|..:.....|.|.|.    :|:.|.:. .|..:::             :.|.:|   ||  :
Human    43 VDNEAQLKASGSISQQDTSGEKLSLKQKIE-KFTRKNI-------------WASLLGKNWEE--H 91

  Fly   159 ASEDRDDEPEDSFQLKPRPDEIENR-ELSRPSQLGSRLNHSANF-------------IYKCAVCP 209
            :.:|:.:..|......||   :|.. :.|:.::.|.....:.|.             .|:|:.|.
Human    92 SVKDKHNTKERHLSRNPR---VERPCKSSKGNKRGRTFRKTRNCNRHLRKNCCTSVRRYECSQCG 153

  Fly   210 RVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAI 274
            ::|..|.||.|| .:||.               |..|..|:.|.:.|.|...|:.|
Human   154 KLFTHSSSLIRH-KRAHS---------------GQKLYKCKECGKAFSRPSYLQTH--------- 193

  Fly   275 ALEPEETTDNSARKRIAKRRDCPHCGLSFPVS-SLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSL 338
                |:|  :|..|..|    |..||.:|..| |||.|:|.|||:.||:|.||.|.|...:....
Human   194 ----EKT--HSGEKPYA----CQSCGKTFLRSHSLTEHVRTHTGEKPYECGQCGKGFSCPKSFRA 248

  Fly   339 HMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGER 403
            |:..|.|.||.|||.|.|.|..|.....||.:|.|.|||.||.|.|::..:...:.|:|.|.||:
Human   249 HVMMHAGGRPYECKHCGKAFRCQKSFRVHMIMHAGGRPYECKQCGKAYCWATSFQRHVRIHNGEK 313

  Fly   404 PYQCGVCGESFVCGSHLNIHRNRKGHL-IAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQ 467
            ||:||.||::|  |...::|::.:.|. ...:.|..|..:.|         ..|.|.|::....:
Human   314 PYKCGKCGKAF--GWPSSLHKHARTHAKKKPVSGGSVGKSSA---------RPRPSTDVKSQTRE 367

  Fly   468 RIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSH 515
            ::                     |||..|.:.:  |...::|:::..|
Human   368 KV---------------------YKCETCGKTY--GWSSSLHKHERKH 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	12/55 (22%)
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	43/97 (44%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	14/22 (64%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
ZNF556	NP_079243.1	KRAB	<14..43	CDD:279668	13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..125		7/34 (21%)
		C2H2 Zn finger	123..139	CDD:275368	2/15 (13%)
		COG5048	<146..294	CDD:227381	66/182 (36%)
		C2H2 Zn finger	149..169	CDD:275368	8/20 (40%)
		zf-H2C2_2	161..186	CDD:290200	11/40 (28%)
		zf-C2H2	175..197	CDD:278523	8/36 (22%)
		C2H2 Zn finger	177..197	CDD:275368	8/34 (24%)
		zf-H2C2_2	189..214	CDD:290200	11/43 (26%)
		C2H2 Zn finger	205..225	CDD:275368	10/19 (53%)
		zf-H2C2_2	217..242	CDD:290200	15/24 (63%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	261..281	CDD:275368	8/19 (42%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	301..324	CDD:290200	11/22 (50%)
		C2H2 Zn finger	317..337	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..365		8/42 (19%)
		C2H2 Zn finger	372..392	CDD:275368	4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..406		2/7 (29%)
		C2H2 Zn finger	427..447	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840