DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF669

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_079080.2	Gene:	ZNF669 / 79862	HGNCID:	25736	Length:	464	Species:	Homo sapiens

Alignment Length:	454	Identity:	117/454 - (25%)
Similarity:	177/454 - (38%)	Gaps:	121/454 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VHDEIKYNDLKL----ELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRL--IGAYEFIVEVENAH 86
            :.|.:.:.|:.:    |.|.||::..|        ||...:.|...|.|  :|:......:|:..
Human    86 IQDSVAFEDVAVNFTQEEWALLDSSQK--------NLYREVMQETCRNLASVGSQWKDQNIEDHF 142

  Fly    87 E----TLQNLFEQQEVAAKPDEVHVDVVELI---DQDDVVSMA-----------QYLSTSFAEQH 133
            |    .::|...|:...:|.|..:.:||..|   |.::.:|..           .::..|...:|
Human   143 EKPGKDIRNHIVQRLCESKEDGQYGEVVSQIPNLDLNENISTGLKPCECSICGKVFVRHSLLNRH 207

  Fly   134 VEM--------EEKYGDQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRPSQ 190
            :..        |::|..:.|..|.                                   :|.|..
Human   208 ILAHSGYKPYGEKQYKCEQCGKFF-----------------------------------VSVPGV 237

  Fly   191 LGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRT 255
            ....:.||.|..|||.:|.:.|....|:.|| .:.|               .|.....|:.|.:.
Human   238 RRHMIMHSGNPAYKCTICGKAFYFLNSVERH-QRTH---------------TGEKPYKCKQCGKA 286

  Fly   256 FKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVS-SLTIHIRRHTGDN 319
            |....:...|              |.|...     .|..:|..||.:|..| |...|.|.|||:.
Human   287 FTVSGSCLIH--------------ERTHTG-----EKPYECKECGKTFRFSCSFKTHERTHTGER 332

  Fly   320 PYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSK 384
            ||||.:|:|||..|..|..|...||||||.|||.|.|.|...:.|..|...|||::||.||.|.:
Human   333 PYKCTKCDKAFSCSTSLRYHGSIHTGERPYECKQCGKAFSRLSSLCNHRSTHTGEKPYECKQCDQ 397

  Fly   385 SFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPY 448
            :|.:.:.|.:|.|.||||:||:|..||:::...|||.  |:.:.|        ::||..:...|
Human   398 AFSRLSSLHLHERIHTGEKPYECKKCGKAYTRSSHLT--RHERSH--------DIEAGCSDSAY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	15/73 (21%)
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	3/16 (19%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	13/22 (59%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
ZNF669	NP_079080.2	KRAB	90..>132	CDD:214630	12/49 (24%)
		KRAB	90..129	CDD:279668	11/46 (24%)
		C2H2 Zn finger	167..183	CDD:275368	4/15 (27%)
		COG5048	<178..436	CDD:227381	89/329 (27%)
		C2H2 Zn finger	191..211	CDD:275368	2/19 (11%)
		C2H2 Zn finger	252..272	CDD:275368	6/20 (30%)
		zf-H2C2_2	264..288	CDD:290200	7/39 (18%)
		C2H2 Zn finger	280..300	CDD:275368	5/33 (15%)
		zf-H2C2_2	296..315	CDD:290200	7/37 (19%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		zf-H2C2_2	320..345	CDD:290200	14/24 (58%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		zf-H2C2_2	348..373	CDD:290200	14/24 (58%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		zf-H2C2_2	379..401	CDD:290200	10/21 (48%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		zf-H2C2_2	408..429	CDD:290200	11/20 (55%)
		C2H2 Zn finger	420..440	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930