DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF329

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_011525612.1	Gene:	ZNF329 / 79673	HGNCID:	14209	Length:	564	Species:	Homo sapiens

Alignment Length:	554	Identity:	145/554 - (26%)
Similarity:	213/554 - (38%)	Gaps:	136/554 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DLKLELW-QLLEAVSKLKWTWTDPNLPMHLCQNC-ARRLIGAYEFIVEVENAHETL---QNLFEQ 95
            |:::|.: :.:..:|.|...|...|...||.|:. .....|..|.|.|.....|.|   .:|...
Human    41 DVEVERFTREVPCLSSLGDGWDCENQEGHLRQSALTLEKPGTQEAICEYPGFGEHLIASSDLPPS 105

  Fly    96 QEVAA-----KPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDC--SAFTSDV- 152
            |.|.|     .||    ..|..:|.|..:       .|:.:.:.  :::.||.|.  ..|...:
Human   106 QRVLATNGFHAPD----SNVSGLDCDPAL-------PSYPKSYA--DKRTGDSDACGKGFNHSME 157

  Fly   153 ---GEEPLYASEDRDDEPEDSFQ----------LKPRPDEIENRELSRPSQLGSRLNHSANFI-- 202
               |..|:.....:..|...||.          :|......|.:.......|.|.||.:...:
Human   158 VIHGRNPVREKPYKYPESVKSFNHFTSLGHQKIMKRGKKSYEGKNFENIFTLSSSLNENQRNLPG 222

  Fly   203 ---YKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRR 264
               |:|..|.:.|.::.||..|    |:            ...|....||..|.::|.:...|..
Human   223 EKQYRCTECGKCFKRNSSLVLH----HR------------THTGEKPYTCNECGKSFSKNYNLIV 271

  Fly   265 HMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEK 328
            | |..|..                  .|..:|..||.:| ..|:||.|.|.|||:.||:|.:|.|
Human   272 H-QRIHTG------------------EKPYECSKCGKAFSDGSALTQHQRIHTGEKPYECLECGK 317

  Fly   329 AFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLK 393
            .|.|:..|.||.|.||||:|..|..|.|.|...:.|..|:|:|||::||.|..|.|:|...:.|.
Human   318 TFNRNSSLILHQRTHTGEKPYRCNECGKPFTDISHLTVHLRIHTGEKPYECSKCGKAFRDGSYLT 382

  Fly   394 IHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRS 458
            .|.|.||||:|::|..||:||...|||.:|:               :.:....||......:...
Human   383 QHERTHTGEKPFECAECGKSFNRNSHLIVHQ---------------KIHSGEKPYECKECGKTFI 432

  Fly   459 EDIERMRLQRIPE-------NQLQQRLENL------------PKPDVPAMCYKCGVCEQKFKSGA 504
            |....:|.|||..       ||.|:...|:            .||      |:|..|.:.|:..:
Human   433 ESAYLIRHQRIHTGEKPYGCNQCQKLFRNIAGLIRHQRTHTGEKP------YECNQCGKAFRDSS 491

  Fly   505 LLTVHRNKMSHYEIERVY--ENPF-----GKNQK 531
            .||.|         :|::  |.|:     ||:.|
Human   492 CLTKH---------QRIHTKETPYQCPECGKSFK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	15/60 (25%)
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	44/97 (45%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	12/22 (55%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	8/16 (50%)
ZNF329	XP_011525612.1	COG5048	200..562	CDD:227381	109/382 (29%)
		zf-C2H2	226..248	CDD:278523	8/37 (22%)
		C2H2 Zn finger	228..248	CDD:275368	7/35 (20%)
		zf-H2C2_2	240..264	CDD:290200	8/39 (21%)
		C2H2 Zn finger	256..276	CDD:275368	6/20 (30%)
		zf-H2C2_2	268..292	CDD:290200	8/42 (19%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		zf-H2C2_2	324..348	CDD:290200	12/23 (52%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		zf-H2C2_2	352..375	CDD:290200	11/22 (50%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		zf-H2C2_2	380..405	CDD:290200	13/24 (54%)
		C2H2 Zn finger	396..416	CDD:275368	9/34 (26%)
		zf-H2C2_2	408..431	CDD:290200	5/37 (14%)
		C2H2 Zn finger	424..444	CDD:275368	4/19 (21%)
		C2H2 Zn finger	452..472	CDD:275368	4/19 (21%)
		zf-H2C2_2	465..487	CDD:290200	5/27 (19%)
		DUF45	<480..547	CDD:302795	12/46 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/28 (25%)
		zf-H2C2_2	493..517	CDD:290200	9/33 (27%)
		C2H2 Zn finger	508..528	CDD:275368	3/9 (33%)
		C2H2 Zn finger	536..556	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840