Protein Alignment CG3281 and ZNF557

DIOPT Version :10

• Sequence 1: NP_650132.1
• Gene: CG3281 / 41445
• FlyBaseID: FBgn0260741
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_077317.2
• Gene: ZNF557 / 79230
• HGNCID: 28632
• Length: 430
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 132/525 - (25%)
• Similarity: 191/525 - (36%)
• Gaps: 192/525 - (36%)

  Fly    32 IKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQ 96
            :.:.|:.:|..|       .:|...||          |:|.:  |..:: :||.    :||....
Human    43 VTFEDVAVEFTQ-------EEWALLDP----------AQRTL--YRDVM-LENC----RNLASLG 83

  Fly    97 EVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYASE 161
            ....||     .::..::|:|.|                |.|:.|  ..|....|| |.|..|.
Human    84 NQVDKP-----RLISQLEQEDKV----------------MTEERG--ILSGTCPDV-ENPFKAK- 123

  Fly   162 DRDDEPEDSFQLKP-----RPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRH 221
                      .|.|     |.::..|.::.| :.||:.||       :|..|.:||:...|||||
Human   124 ----------GLTPKLHVFRKEQSRNMKMER-NHLGATLN-------ECNQCFKVFSTKSSLTRH 170

  Fly   222 FSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTD--- 283
             .:.|               .|.....|..|.:::..:..|..|.:..:.:    :|.|..|
Human   171 -RKIH---------------TGERPYGCSECGKSYSSRSYLAVHKRIHNGE----KPYECNDCGK 215

  Fly   284 -------NSARKRI---AKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYK--------------- 322
                   .:..|||   .|..:|..||.:|..|| |..|:|.|||:.|||
Human   216 TFSSRSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCFREFRTQSIFT 280

  Fly   323 -------------CDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQ 374
                         |:||.|||.....||.|...||||.|.||..|.:.|..::.|.:|:|.|||:
Human   281 RHKRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSNLTQHIRTHTGE 345

  Fly   375 RPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEV 439
            :||:|..|.|||..|..|.||.|.|.||:.|:|..||:||      |:..:.|.|:
Human   346 KPYTCNECGKSFTNSFSLTIHRRIHNGEKSYECSDCGKSF------NVLSSVKKHM--------- 395

  Fly   440 EANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGA 504
                                                 |.....||      |:|..|.:.|.|.:
Human   396 -------------------------------------RTHTGKKP------YECNYCGKSFTSNS 417

  Fly   505 LLTVH 509
            .|:||
Human   418 YLSVH 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	15..91	CDD:214871	11/58 (19%)
		C2H2 Zn finger	205..226	CDD:275368	9/20 (45%)
		C2H2 Zn finger	249..266	CDD:275368	3/16 (19%)
		COG5048	<294..>391	CDD:227381	47/125 (38%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:463886	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	10/19 (53%)
		zf-H2C2_2	391..416	CDD:463886	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
ZNF557	NP_077317.2	KRAB	43..100	CDD:214630	16/85 (19%)
		COG5048	<137..422	CDD:227381	100/370 (27%)
		C2H2 Zn finger	154..174	CDD:275368	9/20 (45%)
		C2H2 Zn finger	182..202	CDD:275368	4/19 (21%)
		C2H2 Zn finger	210..230	CDD:275368	3/19 (16%)
		C2H2 Zn finger	238..258	CDD:275368	9/19 (47%)
		C2H2 Zn finger	266..286	CDD:275368	0/19 (0%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	10/19 (53%)
		C2H2 Zn finger	378..398	CDD:275368	9/71 (13%)
		C2H2 Zn finger	406..426	CDD:275368	7/17 (41%)