DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZBTB17

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001274532.1	Gene:	ZBTB17 / 7709	HGNCID:	12936	Length:	810	Species:	Homo sapiens

Alignment Length:	507	Identity:	138/507 - (27%)
Similarity:	196/507 - (38%)	Gaps:	135/507 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 EQQEVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLY 158
            ||.|.|..|.|  ...||| ..|....||.      ||....:.|. .:|:.....:..|||...
Human   181 EQTEKADAPRE--PPPVEL-KPDPTSGMAA------AEAEAALSES-SEQEMEVEPARKGEEEQK 235

  Fly   159 ASEDRDDE-------PEDSFQLK--PRPDEIENRELS---------------RPSQLGSRLNHSA 199
            ..|::::|       .|:..||:  ..|:|.||.|.:               |....|.|....|
Human   236 EQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA 300

  Fly   200 --NFIYKCAVCPRVFAKSESLTRH---------FS--QAHKLTADVAAMKLAN-----------E 240
              :.|:||..|.:.|..:.:..||         ||  :..|..:|.||.|...           |
Human   301 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCE 365

  Fly   241 SCG-----TGLLT-------------CEHCPRTFKRQDTLRRHM---------------QAFHPD 272
            .||     ..||.             ||.|.:.|.....|:||.               ::|...
Human   366 ECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDP 430

  Fly   273 AIALEPEETTDNSARKRIAKRRDCPHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDL 336
            ...:...||.|..      |...||||...| .|.:|..|::.|..|.|.||.:|.|.|..|.:|
Human   431 TSKMRHLETHDTD------KEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNL 489

  Fly   337 SLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTG 401
            ..|:|.|:||:|..|..|.::|.....|.||:|:|||::|..|.||.|:|.|::.|..|:|:|||
Human   490 KRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTG 554

  Fly   402 ERPYQCGVCGESFVCGS----HLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIE 462
            |:||.|..||:.||..|    |:..|.|.:.|..:|          .:..:||.       .|:.
Human   555 EKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSV----------CSKAFVNV-------GDLS 602

  Fly   463 RMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKS--GALLTVHRNK 512
            :..:....|.              |.:|.|||....:..:  ..:.|||:.|
Human   603 KHIIIHTGEK--------------PYLCDKCGRGFNRVDNLRSHVKTVHQGK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	7/31 (23%)
		C2H2 Zn finger	249..266	CDD:275368	6/16 (38%)
		COG5048	<294..>391	CDD:227381	41/97 (42%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	9/22 (41%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	7/20 (35%)
ZBTB17	NP_001274532.1	BTB	14..109	CDD:279045
		BTB	25..109	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..295		31/123 (25%)
		Interaction with MYC	269..308		6/38 (16%)
		COG5048	306..637	CDD:227381	101/367 (28%)
		zf-C2H2	306..328	CDD:278523	6/21 (29%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	320..344	CDD:290200	5/23 (22%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		zf-C2H2	390..412	CDD:278523	7/21 (33%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..428	CDD:290200	3/23 (13%)
		C2H2 Zn finger	420..440	CDD:275368	2/19 (11%)
		zf-C2H2	446..468	CDD:278523	8/21 (38%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		zf-C2H2	475..496	CDD:278523	9/20 (45%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		zf-H2C2_2	488..512	CDD:290200	9/23 (39%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		zf-H2C2_2	516..541	CDD:290200	13/24 (54%)
		C2H2 Zn finger	532..552	CDD:275368	9/19 (47%)
		zf-H2C2_2	544..569	CDD:290200	13/24 (54%)
		C2H2 Zn finger	560..580	CDD:275368	7/19 (37%)
		zf-H2C2_2	573..597	CDD:290200	5/33 (15%)
		C2H2 Zn finger	588..608	CDD:275368	4/36 (11%)
		zf-H2C2_2	600..625	CDD:290200	7/38 (18%)
		C2H2 Zn finger	616..635	CDD:275370	4/18 (22%)
		C2H2 Zn finger	726..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910