Protein Alignment CG3281 and ZNF133

DIOPT Version :10

• Sequence 1: NP_650132.1
• Gene: CG3281 / 41445
• FlyBaseID: FBgn0260741
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001374224.1
• Gene: ZNF133 / 7692
• HGNCID: 12917
• Length: 691
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 115/405 - (28%)
• Similarity: 157/405 - (38%)
• Gaps: 107/405 - (26%)

  Fly   157 LYASEDRDDEPEDSFQLKPRPDEIE---------NRELSRPSQLGSRLN-HSANFIYKCAVCPRV 211
            |.||..:...||::.:|..|.:.:.         ....|:.:.|.|... ||....|.|.||.:.
Human   223 LEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKG 287

  Fly   212 FAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIAL 276
            |:..:||.|| .:||.               |...:.|..|.|.|.|:.||..|
Human   288 FSLKKSLARH-QKAHS---------------GEKPIVCRECGRGFNRKSTLIIH----------- 325

  Fly   277 EPEETTDNSARKRIAKRRDCPHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRS------- 333
               |.|.:..:..:     |..||..| ..|:|.||.|.|:|:.||.|.:|.|.|.:.
Human   326 ---ERTHSGEKPYM-----CSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQ 382

  Fly   334 ---------------------QDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPY 377
                                 .:|..|.|.|:||:|..||.|.:.|..:..|..|.|.|:.::||
Human   383 RTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPY 447

  Fly   378 SCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEAN 442
            .|.:|..||.|::.|..|.|.||||:||.|||||..|...||||.|:|        |...|
Human   448 VCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQN--------IHSGE---- 500

  Fly   443 FAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLT 507
               .|.|.....:..|:....:|.||....:         ||.|      ||.|.:.|...:.|.
Human   501 ---KPIVCKDCGRGFSQQSNLIRHQRTHSGE---------KPMV------CGECGRGFSQKSNLV 547

  Fly   508 VHRNKMSHYEIERVY 522
            .|:...|.   ||.|
Human   548 AHQRTHSG---ERPY 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	15..91	CDD:214871
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	7/16 (44%)
		COG5048	<294..>391	CDD:227381	39/125 (31%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	7/47 (15%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:463886	10/23 (43%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:463886	15/24 (63%)
		C2H2 Zn finger	407..424	CDD:275368	10/16 (63%)
ZNF133	NP_001374224.1	KRAB	1..60	CDD:214630
		COG5048	252..661	CDD:227381	108/376 (29%)
		C2H2 Zn finger	253..273	CDD:275368	3/19 (16%)
		C2H2 Zn finger	281..301	CDD:275368	8/20 (40%)
		C2H2 Zn finger	309..329	CDD:275368	9/33 (27%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		C2H2 Zn finger	365..385	CDD:275368	4/19 (21%)
		C2H2 Zn finger	393..413	CDD:275368	3/19 (16%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	12/27 (44%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..664	CDD:275368