DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3281 and ZNF70

DIOPT Version :9

Sequence 1:NP_650132.1 Gene:CG3281 / 41445 FlyBaseID:FBgn0260741 Length:538 Species:Drosophila melanogaster
Sequence 2:NP_068735.1 Gene:ZNF70 / 7621 HGNCID:13140 Length:446 Species:Homo sapiens


Alignment Length:488 Identity:132/488 - (27%)
Similarity:186/488 - (38%) Gaps:125/488 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 ENAHETLQNLF---------------EQQEVAAK------PDEVHVDVVELIDQDDVVSMAQYLS 126
            ||..|:.|.||               ||..|..|      .||         :.||........|
Human    16 ENRLESQQGLFPGEDLGDPFLQERGLEQMAVIYKEIPLGEQDE---------ENDDYEGNFSLCS 71

  Fly   127 TSFAEQHV------EMEEKYGD-----QDCSAFTSDVGEEPL---YASEDRDDEPEDSFQLKPRP 177
            :....|.:      :.:|.:|.     .|.|.......|||.   .|..||.|...::....|:|
Human    72 SPVQHQSIPPGTRPQDDELFGQTFLQKSDLSMCQIIHSEEPSPCDCAETDRGDSGPNAPHRTPQP 136

  Fly   178 DE-IENRELSRPSQLGSRL-----NHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMK 236
            .: ...||..:.....|.|     .|:....|:|..|.:.|::|..|.|| ...|          
Human   137 AKPYACRECGKAFSQSSHLLRHLVIHTGEKPYECCECGKAFSQSSHLLRH-QIIH---------- 190

  Fly   237 LANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKR-RDCPHCG 300
                 .|.....|..|.:.|::...|.:| |..|                   ..|| .:|..||
Human   191 -----TGEKPYECRECGKAFRQSSALTQH-QKIH-------------------TGKRPYECRECG 230

  Fly   301 LSFP-VSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKL 364
            ..|. .|||..|.|.|||:.||:|.:|.|:|.:|..||.|.:.||.::|.||.:|.|.|..::.|
Human   231 KDFSRSSSLRKHERIHTGERPYQCKECGKSFNQSSGLSQHRKIHTLKKPHECDLCGKAFCHRSHL 295

  Fly   365 ARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGS----HLNIHRN 425
            .||.|:|||::||.|..|.|:|.||::|..|.:.||||:||:|..||::|...|    |..||..
Human   296 IRHQRIHTGKKPYKCDECGKAFSQSSNLIEHRKTHTGEKPYKCQKCGKAFSQSSSLIEHQRIHTG 360

  Fly   426 RKG-----------HLIAVIPGNEVEANFAADPYV--NARVNQRRSEDIERMRLQRIPENQLQQR 477
            .|.           |..|:|....:..  ...||.  ..:..:.||..||            ..:
Human   361 EKPYECCQCGKAFCHSSALIQHQRIHT--GKKPYTCECGKAFRHRSALIE------------HYK 411

  Fly   478 LENLPKPDVPAMCYKCGVCEQKFKSGALLTVHR 510
            .....||      |.|.:|.:.|:..:.|..|:
Human   412 THTREKP------YVCNLCGKSFRGSSHLIRHQ 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3281NP_650132.1 zf-AD 14..92 CDD:285071 4/8 (50%)
C2H2 Zn finger 205..226 CDD:275368 7/20 (35%)
C2H2 Zn finger 249..266 CDD:275368 4/16 (25%)
COG5048 <294..>391 CDD:227381 45/97 (46%)
C2H2 Zn finger 296..315 CDD:275368 9/19 (47%)
zf-H2C2_2 307..330 CDD:290200 12/22 (55%)
C2H2 Zn finger 323..343 CDD:275368 8/19 (42%)
zf-H2C2_2 335..358 CDD:290200 10/22 (45%)
C2H2 Zn finger 351..371 CDD:275368 8/19 (42%)
zf-H2C2_2 364..388 CDD:290200 13/23 (57%)
C2H2 Zn finger 379..399 CDD:275368 8/19 (42%)
zf-H2C2_2 391..416 CDD:290200 12/24 (50%)
C2H2 Zn finger 407..424 CDD:275368 7/20 (35%)
ZNF70NP_068735.1 C2H2 Zn finger 92..108 CDD:275368 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..138 6/23 (26%)
COG5048 138..442 CDD:227381 103/357 (29%)
C2H2 Zn finger 142..162 CDD:275368 4/19 (21%)
C2H2 Zn finger 170..190 CDD:275368 7/20 (35%)
C2H2 Zn finger 198..218 CDD:275368 6/20 (30%)
C2H2 Zn finger 226..246 CDD:275368 9/19 (47%)
C2H2 Zn finger 254..274 CDD:275368 8/19 (42%)
C2H2 Zn finger 282..302 CDD:275368 8/19 (42%)
C2H2 Zn finger 310..330 CDD:275368 8/19 (42%)
C2H2 Zn finger 338..358 CDD:275368 6/19 (32%)
C2H2 Zn finger 366..386 CDD:275368 3/19 (16%)
C2H2 Zn finger 394..413 CDD:275368 4/30 (13%)
C2H2 Zn finger 421..441 CDD:275368 5/18 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146681
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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