DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF69

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	538	Identity:	141/538 - (26%)
Similarity:	214/538 - (39%)	Gaps:	127/538 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEV 98
            |.::.||.::.|.:|.|   :|.|.|:              .||:    :|.....::|.|::..
Human    52 YKEVMLETFRNLTSVGK---SWKDQNI--------------EYEY----QNPRRNFRSLIEKKVN 95

  Fly    99 AAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPL----YA 159
            ..|.|....:....:..|.:         :|.|:....|.|    .|.:|.  .||..|    :.
Human    96 EIKDDSHCGETFTQVPDDRL---------NFQEKKASPEIK----SCDSFV--CGEVGLGNSSFN 145

  Fly   160 SEDRDDEPEDSFQLK---PRPDEIENRELS---RPSQLGSRLNHSANFIYKCAVCPRVFAKSESL 218
            ...|.|....:::.:   |:|.:.:..:.:   .||....:.:|:....|.|..|.:.|....|:
Human   146 MNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYHPSFRTPQRDHTGEKPYACKECGKTFISHSSI 210

  Fly   219 TRHF---------------SQAHKLTADVAAMKLANESCGTG--LLTCEHCPRTFKRQDTLRRHM 266
            .||.               ...|.|     ::.|.:|...||  ...|:.|.::|....|||.|.
Human   211 QRHVVMHSGDGPYKCKFCGKAFHCL-----SLYLIHERIHTGEKPYECKQCGKSFSYSATLRIHE 270

  Fly   267 ---------------QAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSS-LTIHIRRH 315
                           :|||........|......      |...|..||.:|.... :.||.|.|
Human   271 RTHTGEKPYECQQCGKAFHSPRCYRRHERIHTGE------KAYQCKECGKAFTCPQYVRIHERTH 329

  Fly   316 TGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCK 380
            :...||:|.||.||.........|:|.|:||||.|||||.|.|.|.|...||.:.|:|::||.||
Human   330 SRKKPYECTQCGKALSSLTSFQTHIRMHSGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCK 394

  Fly   381 MCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIH-RNRKGHLIAVIPGNEVEANFA 444
            .|.|:|:.|:.|:.|.|.||||:||:|..||::|...|||.:| |...|.
Human   395 QCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGE--------------- 444

  Fly   445 ADPYVNARVNQRRSEDIERMR-LQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKF---KSGAL 505
             .||    ..|...:....|: ||.....|...|:.:..:|      |||.:|.:.|   ||
Human   445 -KPY----ECQECGKAFRSMKNLQSHERTQTHVRIHSGERP------YKCKLCGKGFYCPKS--- 495

  Fly   506 LTVHRNKMSHYEIERVYE 523
              :.|::.:|.. |::||
Human   496 --LQRHEKTHTG-EKLYE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	12/57 (21%)
		C2H2 Zn finger	205..226	CDD:275368	6/35 (17%)
		C2H2 Zn finger	249..266	CDD:275368	6/16 (38%)
		COG5048	<294..>391	CDD:227381	43/97 (44%)
		C2H2 Zn finger	296..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..330	CDD:290200	10/23 (43%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	13/22 (59%)
		C2H2 Zn finger	351..371	CDD:275368	10/19 (53%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	8/17 (47%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630	4/14 (29%)
		KRAB	27..66	CDD:279668	4/13 (31%)
		C2H2 Zn finger	169..189	CDD:275368	2/19 (11%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		COG5048	222..>540	CDD:227381	101/332 (30%)
		C2H2 Zn finger	225..245	CDD:275368	4/24 (17%)
		zf-H2C2_2	241..262	CDD:290200	6/20 (30%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..290	CDD:290200	5/23 (22%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		zf-H2C2_2	295..318	CDD:290200	6/28 (21%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	349..372	CDD:290200	13/22 (59%)
		C2H2 Zn finger	365..385	CDD:275368	10/19 (53%)
		zf-H2C2_2	377..400	CDD:290200	10/22 (45%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		zf-H2C2_2	405..430	CDD:290200	13/24 (54%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..468	CDD:275368	4/18 (22%)
		C2H2 Zn finger	483..503	CDD:275368	6/24 (25%)
		zf-H2C2_2	495..520	CDD:290200	6/22 (27%)
		C2H2 Zn finger	511..531	CDD:275368	141/538 (26%)
		zf-H2C2_2	523..546	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930