DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF35

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_003411.3	Gene:	ZNF35 / 7584	HGNCID:	13099	Length:	527	Species:	Homo sapiens

Alignment Length:	547	Identity:	137/547 - (25%)
Similarity:	200/547 - (36%)	Gaps:	188/547 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LETHETNLYVHDEIKYNDL---KLELWQ-------LLEAVSKLKWTWTDPNLPMHLCQNCARRLI 73
            ||||.|..::..|.|...|   |.|:.:       :.|.:.|     .||..| .|.:.|.:
Human   103 LETHGTMNFLGAETKNLQLLVPKTEICEEAEKPLIISERIQK-----ADPQGP-ELGEACEK--- 158

  Fly    74 GAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEE 138
                            .|:.::|.:..          |..|...|:....:|..||.|:..:..:
Human   159 ----------------GNMLKRQRIKR----------EKKDFRQVIVNDCHLPESFKEEENQKCK 197

  Fly   139 KYGDQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRPSQL------------ 191
            |.|           |:..|.:...::  |:.....||....:..:..|:.:.|
Human   198 KSG-----------GKYSLNSGAVKN--PKTQLGQKPFTCSVCGKGFSQSANLVVHQRIHTGEKP 249

  Fly   192 ------GSRLNHSANFI-----------YKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLAN 239
                  |.....|||.:           |.|:.|.:.|.:|.:||.| .:.|.|..
Human   250 FECHECGKAFIQSANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVH-QKIHSLEK--------- 304

  Fly   240 ESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFP 304
                  ...|..|.:.|.....|.|| |..|          .|:        |..:|..||.:|.
Human   305 ------TFKCNECEKAFSYSSQLARH-QKVH----------ITE--------KCYECNECGKTFT 344

  Fly   305 VSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHM 368
            .|| |.:|.|.|||:.|:.|:.|.|||.:|.:|.:|.|.||||:|.|||.|.|.|...:.|..|.
Human   345 RSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYECKECGKAFSCFSHLIVHQ 409

  Fly   369 RLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAV 433
            |:||.::||.|..|.|:|.|.:.|.:|.|.|:|:.||.|..||::|.|.|:|.||
Human   410 RIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTCSSYLLIH---------- 464

  Fly   434 IPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQ 498
                                                      ||:.|..||      |.|..|.:
Human   465 ------------------------------------------QRIHNGEKP------YTCNECGK 481

  Fly   499 KFKSGALLTVHRNKMSH-----YEIER 520
            .|:..:.||||:.  :|     ||.|:
Human   482 AFRQRSSLTVHQR--THTGEKPYECEK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	17/82 (21%)
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	11/23 (48%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	13/22 (59%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:290200	11/24 (46%)
		C2H2 Zn finger	407..424	CDD:275368	8/16 (50%)
ZNF35	NP_003411.3	Globular domain	9..221		31/165 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		COG5048	<214..369	CDD:227381	43/189 (23%)
		C2H2 Zn finger	224..244	CDD:275368	2/19 (11%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		C2H2 Zn finger	280..300	CDD:275368	7/20 (35%)
		C2H2 Zn finger	308..328	CDD:275368	7/20 (35%)
		C2H2 Zn finger	336..356	CDD:275368	9/19 (47%)
		C2H2 Zn finger	364..384	CDD:275368	9/19 (47%)
		COG5048	372..>449	CDD:227381	34/76 (45%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	11/71 (15%)
		zf-H2C2_2	460..485	CDD:316026	12/82 (15%)
		zf-C2H2	474..496	CDD:306579	8/23 (35%)
		C2H2 Zn finger	476..496	CDD:275368	7/21 (33%)
		zf-H2C2_2	488..513	CDD:316026	8/21 (38%)
		C2H2 Zn finger	504..524	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840