DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF19

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_008892.2	Gene:	ZNF19 / 7567	HGNCID:	12981	Length:	458	Species:	Homo sapiens

Alignment Length:	521	Identity:	130/521 - (24%)
Similarity:	193/521 - (37%)	Gaps:	143/521 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELI 113
            :|.:||...|          |:|.:  |..:: :||    ..||........||     .::.|:
Human    24 TKTEWTGLSP----------AQRAL--YRSVM-LEN----FGNLTALGYPVPKP-----ALISLL 66

  Fly   114 DQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLY---ASEDRDDEPEDSFQLK- 174
            ::.|:....:......||:...:        |....:::..|...   .||:||...... |||
Human    67 ERGDMAWGLEAQDDPPAERTKNV--------CKDVETNIDSESTLIQGISEERDGMMSHG-QLKS 122

  Fly   175 --PRPDEIENRELSRPSQLGSRLNHSAN----------FIYKCAVCPRVFAKSESLTRHFSQAHK 227
              .|.|..|.|.:.:...:.:..|....          ||  |..|.:.|:......|| .:.|
Human   123 VPQRTDFPETRNVEKHQDIPTVKNIQGKVPRIPCARKPFI--CEECGKSFSYFSYYARH-QRIH- 183

  Fly   228 LTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAK 292
                          .|.....|..|.:.|....:|.|| |..|..                  .:
Human   184 --------------TGEKPFECSECGKAFNGNSSLIRH-QRIHTG------------------ER 215

  Fly   293 RRDCPHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSK 356
            ...|..||.:| ..::|..|.|.|:||.||.|.:|..:|..|.:..:|.|.||||:|.||..|.|
Human   216 PYQCEECGRAFNDNANLIRHQRIHSGDRPYYCTECGNSFTSSSEFVIHQRIHTGEKPYECNECGK 280

  Fly   357 KFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESF----VCG 417
            .|:..:.|.||.::|||::||.|..|.|||.:::.|..|.|.||||:||.|.|||::|    ...
Human   281 AFVGNSPLLRHQKIHTGEKPYECNECGKSFGRTSHLSQHQRIHTGEKPYSCKVCGQAFNFHTKLT 345

  Fly   418 SHLNIHRNRKGHLIAVIPGNEVEAN--FAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLEN 480
            .|..||...|       |.:.|:..  |:|                         :.||::.|
Human   346 RHQRIHSEEK-------PFDCVDCGKAFSA-------------------------QEQLKRHL-- 376

  Fly   481 LPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSH---------YEIERVYENPFGKNQKIIKAE 536
              :.......|.|..|      |..||..||...|         ||..: ||..||.:.::...|
Human   377 --RIHTQESSYVCDEC------GKALTSKRNLHQHQRIHTGEKPYECSK-YEKAFGTSSQLGHLE 432

  Fly   537 Y 537
            :
Human   433 H 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	9/42 (21%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	41/97 (42%)
		C2H2 Zn finger	296..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..330	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:290200	14/28 (50%)
		C2H2 Zn finger	407..424	CDD:275368	7/20 (35%)
ZNF19	NP_008892.2	KRAB	14..73	CDD:214630	15/70 (21%)
		KRAB	14..53	CDD:279668	11/45 (24%)
		COG5048	<96..426	CDD:227381	111/410 (27%)
		C2H2 Zn finger	163..183	CDD:275368	5/20 (25%)
		zf-H2C2_2	178..199	CDD:290200	6/36 (17%)
		C2H2 Zn finger	191..211	CDD:275368	7/20 (35%)
		zf-H2C2_2	203..227	CDD:290200	8/42 (19%)
		C2H2 Zn finger	219..239	CDD:275368	7/19 (37%)
		zf-H2C2_2	231..256	CDD:290200	11/24 (46%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		zf-H2C2_2	263..283	CDD:290200	11/19 (58%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..312	CDD:290200	13/23 (57%)
		C2H2 Zn finger	303..323	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..339	CDD:290200	13/23 (57%)
		C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..367	CDD:290200	6/29 (21%)
		C2H2 Zn finger	359..379	CDD:275368	6/48 (13%)
		zf-H2C2_2	372..393	CDD:290200	6/30 (20%)
		C2H2 Zn finger	387..407	CDD:275368	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840