DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF10

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_056209.2	Gene:	ZNF10 / 7556	HGNCID:	12879	Length:	573	Species:	Homo sapiens

Alignment Length:	612	Identity:	137/612 - (22%)
Similarity:	209/612 - (34%)	Gaps:	220/612 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EIHVNISS-------QTCRVCLETHETNLYVHDEIKYNDLKLELWQLLEAVSKLKWTWTDPNLPM 62
            ||..::||       |:|.:.:|....|     ::.|..|: |:|:..:.:.|.:     .|...
Human    92 EIKSSVSSRSIFKDKQSCDIKMEGMARN-----DLWYLSLE-EVWKCRDQLDKYQ-----ENPER 145

  Fly    63 HLCQNCARRLIGAYEFIVEVENAHET--------------LQNLFEQQEVAAKPDEVHVDVVELI 113
            ||     |::....:.::..|...|:              |:..|.:::...|  .:..|:|...
Human   146 HL-----RQVAFTQKKVLTQERVSESGKYGGNCLLPAQLVLREYFHKRDSHTK--SLKHDLVLNG 203

  Fly   114 DQDDVVSMAQYLSTS---------FAEQH--------------------------VEMEEKYGDQ 143
            .||...|.:.....:         ||..|                          :..|:.|..:
Human   204 HQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKCPDNDNSLTHGSSLGISKGIHREKPYECK 268

  Fly   144 DCSAFTS-----------DVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRPSQL-GSRLN 196
            :|..|.|           ..||:|....|.                   .:..||.|.| |.:..
Human   269 ECGKFFSWRSNLTRHQLIHTGEKPYECKEC-------------------GKSFSRSSHLIGHQKT 314

  Fly   197 HSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDT 261
            |:....|:|..|.:.|:....|..| .:.|               .|..|.||..|.::|.....
Human   315 HTGEEPYECKECGKSFSWFSHLVTH-QRTH---------------TGDKLYTCNQCGKSFVHSSR 363

  Fly   262 LRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYKCDQ 325
            |.||.:....:                   |..:||.||.||..|: |.:|.|.|....||:|::
Human   364 LIRHQRTHTGE-------------------KPYECPECGKSFRQSTHLILHQRTHVRVRPYECNE 409

  Fly   326 CEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSN 390
            |.|::.:...|.:|.|.|||.:|.|||.|.|.|...:.|..|.|.|||::||.|..|.|||.||:
Human   410 CGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSS 474

  Fly   391 DLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQ 455
            .|.:|.|.||||:||:|..||::|:          ||..||
Human   475 ALIVHQRIHTGEKPYECCQCGKAFI----------RKNDLI------------------------ 505

  Fly   456 RRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHR---------- 510
                     :.|||               .|....|||..|...|...:...||:
Human   506 ---------KHQRI---------------HVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQFLT 546

  Fly   511 -----------NKMSHYEIERVYENPF 526
                       :.:..|:...:.||.:
Human   547 CNQCGTALVNTSNLIGYQTNHIRENAY 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	15/91 (16%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	44/97 (45%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	9/23 (39%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	12/22 (55%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	10/19 (53%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	4/16 (25%)
ZNF10	NP_056209.2	KRAB	14..73	CDD:214630
		C2H2 Zn finger	213..232	CDD:275368	2/18 (11%)
		C2H2 Zn finger	267..287	CDD:275368	3/19 (16%)
		COG5048	<272..474	CDD:227381	72/255 (28%)
		C2H2 Zn finger	295..315	CDD:275368	6/38 (16%)
		C2H2 Zn finger	323..343	CDD:275368	5/20 (25%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	10/19 (53%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		C2H2 Zn finger	463..483	CDD:275368	10/19 (53%)
		C2H2 Zn finger	491..511	CDD:275368	11/77 (14%)
		C2H2 Zn finger	519..539	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840