DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Zfp131

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001289476.1	Gene:	Zfp131 / 72465	MGIID:	1919715	Length:	619	Species:	Mus musculus

Alignment Length:	557	Identity:	120/557 - (21%)
Similarity:	232/557 - (41%)	Gaps:	100/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ISSQTCRVCLE-THETNLYVHDEIKYNDL--KLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARR 71
            :|....|..:| |:...|.:..|.:.||:  ..|..|:|||:..|:....:.:.|:.  :|...:
Mouse    77 VSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLE--ENTTGK 139

  Fly    72 LIGAYEFIVEVENA-HETLQNLFEQQEVAAKPDEVHVDVVE---LIDQDDVVSMAQYLSTSFAEQ 132
            .......|.|..|. .|:|.:      ..::|.|:.|::.|   .::.:.:.::.:..|   |:|
Mouse   140 NEAKKRKIAETSNVITESLPS------AESEPVEIEVEIAEGTIEVEDEGIEALEEMAS---AKQ 195

  Fly   133 HVEMEEKYGDQDCSAFT--SDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRPSQLGSRL 195
            .::..:..|..|.||..  :|:..: ....|.:....||.....|...::|..|:     :..:|
Mouse   196 SIKYIQSTGSSDDSALALLADITSK-YRQGESKGQISEDDCASDPISKQVEGIEI-----VELQL 254

  Fly   196 NHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQD 260
            :|..: ::.|..|.|.|    .|..||.:..|             |..|....||.|.:.:.|:.
Mouse   255 SHVKD-LFHCEKCNRSF----KLFYHFKEHMK-------------SHSTESFKCEICNKRYLRES 301

  Fly   261 TLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFP-VSSLTIHIRRHTGDNPYKCD 324
            ..::|:..:|.:...:..::.|..       |...|.:|...|. ......|:|:|||:.|::|.
Mouse   302 AWKQHLNCYHLEEGGVSKKQRTGK-------KIHICQYCDKQFDHFGHFKEHLRKHTGEKPFECS 359

  Fly   325 QCEKAFPRSQDLSLHMRQ-HTG-------ERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKM 381
            .|.:.|.|:..|..|:.. .||       ::..||::|:..|.|.::...|:.:|||.:|..|.:
Mouse   360 NCHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPNHCTL 424

  Fly   382 CSKSFVQSNDLKIHM--RRHTGERPYQCGVCGESFVCGSHLN---------IHRNRKGHLIAVIP 435
            |...|:|.|:|:.|:  ..:..||.    |..|.....:||.         |.:..|.|   |:|
Mouse   425 CDLWFMQGNELRRHLSDAHNISERI----VTEEVLSVETHLQTEPVTSMTIIEQVGKVH---VLP 482

  Fly   436 GNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQL-QQRLENLPKPDVPAMCYKCGVCEQK 499
            ..:|:.:       :|:|.      :|::....:.::|: ..::..||: .|.....:.|    :
Mouse   483 LLQVQVD-------SAQVT------VEQVHPDLLQDSQVHDSQMTGLPE-QVQVSYLEVG----R 529

  Fly   500 FKSGALLTVHRNKMSHYEIERVYENPFGKNQKIIKAE 536
            .::.....||   :....:|||.:.|.....::::|:
Mouse   530 IQTEEGTEVH---VEELHVERVNQMPVEVQTELLEAD 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	20/81 (25%)
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	31/105 (30%)
		C2H2 Zn finger	296..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	307..330	CDD:290200	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	6/20 (30%)
		zf-H2C2_2	335..358	CDD:290200	7/30 (23%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		zf-H2C2_2	364..388	CDD:290200	8/23 (35%)
		C2H2 Zn finger	379..399	CDD:275368	7/21 (33%)
		zf-H2C2_2	391..416	CDD:290200	6/26 (23%)
		C2H2 Zn finger	407..424	CDD:275368	5/25 (20%)
Zfp131	NP_001289476.1	BTB_POZ_ZBTB35_ZNF131	16..128	CDD:349530	14/50 (28%)
		Nuclear localization signal 1. /evidence=ECO:0000250	137..148		0/10 (0%)
		COG5048	<262..444	CDD:227381	52/205 (25%)
		C2H2 Zn finger	263..283	CDD:275368	8/36 (22%)
		C2H2 Zn finger	290..311	CDD:275368	5/20 (25%)
		Nuclear localization signal 2. /evidence=ECO:0000250	317..328		2/17 (12%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..367	CDD:372612	9/24 (38%)
		C2H2 Zn finger	358..375	CDD:275368	5/16 (31%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..439	CDD:275370	6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..619
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000