DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Zfp169

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_011242711.1	Gene:	Zfp169 / 67911	MGIID:	1915161	Length:	732	Species:	Mus musculus

Alignment Length:	361	Identity:	103/361 - (28%)
Similarity:	135/361 - (37%)	Gaps:	96/361 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 QLGSRLNHSANFI-----------YKCAVCPRVFAKSESLTRH------------------FSQA 225
            |.|.......|.|           :.|..|.|.|.....||||                  |||.
Mouse   431 QCGWSFTQKVNLIRHQRIHTEVKPFLCPECGRAFEFKSLLTRHRKTHMGEKPYVCPQCGRGFSQK 495

  Fly   226 HKLTADVAAMKLANESCGTGLL--TCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARK 288
            ..|        :.::...||.|  .|..|.|.|.:|..|.|| |..|..
Mouse   496 FNL--------IGHQRIHTGELPFLCPECGRAFVKQSMLIRH-QRTHAG---------------- 535

  Fly   289 RIAKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECK 352
             ..|...||.||.:|...| ||.|.:.|||:.||.|.||.:.|.:..:|..|.:.||||:|..|.
Mouse   536 -WEKPYQCPECGRTFEFKSLLTRHQKIHTGEKPYVCPQCGRGFSQKFNLIGHQKTHTGEKPYACP 599

  Fly   353 ICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCG 417
            .|.::|..:..||||.|:|||::|:.|..|.::|.:...|..|.|.|..|:||||..||.:|...
Mouse   600 QCGQRFRQKFNLARHQRIHTGEKPFLCAECGRAFGKKVSLIRHQRTHGEEKPYQCTECGRAFEFK 664

  Fly   418 S----HLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRL 478
            |    |...|...|                   |||.....:..|:....:..||....:
Mouse   665 SLFIRHQKTHTGEK-------------------PYVCPECGKAFSQKFNLIGHQRSHTGE----- 705

  Fly   479 ENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMS 514
                ||      |.|..|.:.|...:|||.|:...|
Mouse   706 ----KP------YLCPQCGRAFAFKSLLTRHQRTHS 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	11/38 (29%)
		C2H2 Zn finger	249..266	CDD:275368	7/16 (44%)
		COG5048	<294..>391	CDD:227381	40/97 (41%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	12/23 (52%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	9/22 (41%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	6/20 (30%)
Zfp169	XP_011242711.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	233..252	CDD:275368
		COG5048	256..727	CDD:227381	101/355 (28%)
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..309	CDD:275368
		C2H2 Zn finger	317..337	CDD:275368
		C2H2 Zn finger	345..365	CDD:275368
		C2H2 Zn finger	373..393	CDD:275368
		C2H2 Zn finger	401..421	CDD:275368
		C2H2 Zn finger	429..449	CDD:275368	4/17 (24%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	485..505	CDD:275368	4/27 (15%)
		C2H2 Zn finger	513..533	CDD:275368	9/20 (45%)
		C2H2 Zn finger	542..562	CDD:275368	9/19 (47%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..618	CDD:275368	8/19 (42%)
		C2H2 Zn finger	626..646	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	6/19 (32%)
		C2H2 Zn finger	682..702	CDD:275368	3/19 (16%)
		C2H2 Zn finger	710..730	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930