DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF674

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001034980.1	Gene:	ZNF674 / 641339	HGNCID:	17625	Length:	581	Species:	Homo sapiens

Alignment Length:	616	Identity:	157/616 - (25%)
Similarity:	228/616 - (37%)	Gaps:	170/616 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LETHETNLYVHDEIKYNDLKLELWQLLEAVSKL---------------KWTWTDPNLPMHLCQNC 68
            |::.:.||       |.|:.||.:..|.:|..|               .| ..|...|:..|
Human    25 LDSAQKNL-------YRDVMLENYSHLVSVGHLVGKPDVIFRLGPGDESW-MADGGTPVRTC--- 78

  Fly    69 ARRLIGAYEFIVEVENAHETLQNLFEQQ-----EVAAKPDEVHVDVVELIDQDDVVSMAQYLSTS 128
                  |.|...||....|.:.:..|.|     :.|....|...|  |...:..:.....||:|.
Human    79 ------AGEDRPEVWEVDEQIDHYKESQDKFLWQAAFIGKETLKD--ESGQECKICRKIIYLNTD 135

  Fly   129 FAEQHVEMEEKYGDQDCSA-FTSDVGEEPLYASEDRDD-----------------EP-EDSFQLK 174
            |......:.:.|..:.||. ..:.:|:...|..: :||                 :| |..|...
Human   136 FVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRK-KDDGCKAYWKVCLHYNLHKAQPAERFFDPN 199

  Fly   175 PRPDEIENREL---SRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRH--------------- 221
            .|...:..::.   |:.||.|.:|       |||..|.:||.:..:|..|
Human   200 QRGKALHQKQALRKSQRSQTGEKL-------YKCTECGKVFIQKANLVVHQRTHTGEKPYECCEC 257

  Fly   222 ---FSQ-----AHKLTADVAAMKLANESCGTGLL------------------TCEHCPRTFKRQD 260
               |||     ||:.| ...........||...:                  .|:.||:.||...
Human   258 AKAFSQKSTLIAHQRT-HTGEKPYECSECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSY 321

  Fly   261 TLRRH-----MQAFHPDAIALEPEETTDNSARKRI--AKRRDC-PHCGLSFPVSSLTIHIRRHTG 317
            .|.||     .|||:...     :.||.:...:||  :::..| .|...|....|.|.|.|.||.
Human   322 HLIRHEKTHIRQAFYKGI-----KCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPTKHWRTHTK 381

  Fly   318 DNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMC 382
            :|.|:|.:|.|:|.....||:|.|.||||:|.||.||.|.|..::.|:.|.|.|||::||.|:.|
Human   382 ENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRC 446

  Fly   383 SKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGS----HLNIHRNRKGHLIAVIPGNEVEANF 443
            .|:|.:.:.|.:|.|.||||:||:|..||::|...|    |..||...:
Human   447 GKAFGEKSTLIVHQRMHTGEKPYKCNECGKAFSEKSPLIKHQRIHTGER---------------- 495

  Fly   444 AADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTV 508
               ||......:..|.....::.|||...:         ||      |||..|.:.|...:.|.|
Human   496 ---PYECTDCKKAFSRKSTLIKHQRIHTGE---------KP------YKCSECGKAFSVKSTLIV 542

  Fly   509 HRNKMSHYEIERVYE-----NPFGKNQKIIK 534
            |...   :..|:.||     ..|.....:||
Human   543 HHRT---HTGEKPYECRDCGKAFSGKSTLIK 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	19/87 (22%)
		C2H2 Zn finger	205..226	CDD:275368	9/43 (21%)
		C2H2 Zn finger	249..266	CDD:275368	8/21 (38%)
		COG5048	<294..>391	CDD:227381	42/97 (43%)
		C2H2 Zn finger	296..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..330	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	14/22 (64%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	7/20 (35%)
ZNF674	NP_001034980.1	KRAB	8..68	CDD:214630	11/50 (22%)
		KRAB	8..47	CDD:279668	8/28 (29%)
		COG5048	190..580	CDD:227381	121/431 (28%)
		C2H2 Zn finger	202..218	CDD:275368	1/15 (7%)
		zf-C2H2	224..246	CDD:278523	8/21 (38%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..263	CDD:290200	3/24 (13%)
		C2H2 Zn finger	254..274	CDD:275368	6/20 (30%)
		zf-C2H2	280..302	CDD:278523	2/21 (10%)
		C2H2 Zn finger	282..302	CDD:275368	2/19 (11%)
		zf-H2C2_2	295..319	CDD:290200	4/23 (17%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377		6/19 (32%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..423	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..450	CDD:290200	11/22 (50%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		zf-H2C2_2	456..479	CDD:290200	12/22 (55%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	5/42 (12%)
		C2H2 Zn finger	499..519	CDD:275368	3/19 (16%)
		zf-H2C2_2	512..535	CDD:290200	9/37 (24%)
		C2H2 Zn finger	527..547	CDD:275368	6/22 (27%)
		zf-H2C2_2	540..563	CDD:290200	6/25 (24%)
		C2H2 Zn finger	555..575	CDD:275368	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840