DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3281 and ZNF248

DIOPT Version :9

Sequence 1:NP_650132.1 Gene:CG3281 / 41445 FlyBaseID:FBgn0260741 Length:538 Species:Drosophila melanogaster
Sequence 2:NP_001254526.1 Gene:ZNF248 / 57209 HGNCID:13041 Length:579 Species:Homo sapiens


Alignment Length:566 Identity:154/566 - (27%)
Similarity:219/566 - (38%) Gaps:160/566 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 HDEIKYN-DLKLE---------LWQLL------------EAVSKLKWTWTDP----NLPMHLCQN 67
            |.|.|:. |..||         .|:||            :..||.....|||    |.|..:|.:
Human    78 HPERKWKVDDVLESSQENEDDHFWELLFHNNKTVSVENGDRGSKTFNLGTDPVSLRNYPYKICDS 142

  Fly    68 CARRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELID-----------------Q 115
            |...|......|:..:|...            .||||.:|....|:|                 :
Human   143 CEMNLKNISGLIISKKNCSR------------KKPDEFNVCEKLLLDIRHEKIPIGEKSYKYDQK 195

  Fly   116 DDVVSMAQYLS-TSFAEQHVEMEEKYGDQDCSAF----TSDVGEEPLYASEDRDDEPEDSFQLKP 175
            .:.::..|.|| .||.:.....:...|..|.:||    .|.:||     :..:.:|...:|    
Human   196 RNAINYHQDLSQPSFGQSFEYSKNGQGFHDEAAFFTNKRSQIGE-----TVCKYNECGRTF---- 251

  Fly   176 RPDEIENRELS---RPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKL 237
                ||:.:|:   ||        |.....|.|::|    .||..:...|.....||.|      
Human   252 ----IESLKLNISQRP--------HLEMEPYGCSIC----GKSFCMNLRFGHQRALTKD------ 294

  Fly   238 AN--ESCGTGLLTCEHCP-------------RTFKRQD------TLRRHMQAFHPDAIALEPEET 281
             |  |....|.:.|::..             |.:|..|      .|.:| |..|....:.:..|.
Human   295 -NPYEYNEYGEIFCDNSAFIIHQGAYTRKILREYKVSDKTWEKSALLKH-QIVHMGGKSYDYNEN 357

  Fly   282 TDNSARK------RIA----KRRDCPHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRSQD 335
            ..|.::|      |.|    |..:|..||.:| ..|:||.|.|.|||:.||:|.:|.|||.:...
Human   358 GSNFSKKSHLTQLRRAHTGEKTFECGECGKTFWEKSNLTQHQRTHTGEKPYECTECGKAFCQKPH 422

  Fly   336 LSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHT 400
            |:.|.|.||||:|.|||.|.|.|..::.|..|.|.|||::||.|..|.|||...:.|.:|.|.||
Human   423 LTNHQRTHTGEKPYECKQCGKTFCVKSNLTEHQRTHTGEKPYECNACGKSFCHRSALTVHQRTHT 487

  Fly   401 GERPYQCGVCGESFVCGSHLNIH-RNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERM 464
            ||:|:.|..||:||...|:|.:| |...|.                .||   :.|:......|:.
Human   488 GEKPFICNECGKSFCVKSNLIVHQRTHTGE----------------KPY---KCNECGKTFCEKS 533

  Fly   465 RLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHR 510
            .|.:      .||.....||      |:|..|.:.|...::||.|:
Human   534 ALTK------HQRTHTGEKP------YECNACGKTFSQRSVLTKHQ 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3281NP_650132.1 zf-AD 14..92 CDD:285071 21/88 (24%)
C2H2 Zn finger 205..226 CDD:275368 5/20 (25%)
C2H2 Zn finger 249..266 CDD:275368 5/35 (14%)
COG5048 <294..>391 CDD:227381 46/97 (47%)
C2H2 Zn finger 296..315 CDD:275368 9/19 (47%)
zf-H2C2_2 307..330 CDD:290200 12/22 (55%)
C2H2 Zn finger 323..343 CDD:275368 8/19 (42%)
zf-H2C2_2 335..358 CDD:290200 13/22 (59%)
C2H2 Zn finger 351..371 CDD:275368 8/19 (42%)
zf-H2C2_2 364..388 CDD:290200 13/23 (57%)
C2H2 Zn finger 379..399 CDD:275368 8/19 (42%)
zf-H2C2_2 391..416 CDD:290200 13/24 (54%)
C2H2 Zn finger 407..424 CDD:275368 8/17 (47%)
ZNF248NP_001254526.1 KRAB 8..68 CDD:214630
C2H2 Zn finger 220..236 CDD:275368 4/15 (27%)
C2H2 Zn finger 244..264 CDD:275368 7/35 (20%)
C2H2 Zn finger 358..374 CDD:275368 3/15 (20%)
C2H2 Zn finger 382..402 CDD:275368 9/19 (47%)
COG5048 406..>472 CDD:227381 31/65 (48%)
C2H2 Zn finger 410..430 CDD:275368 8/19 (42%)
C2H2 Zn finger 438..458 CDD:275368 8/19 (42%)
C2H2 Zn finger 466..486 CDD:275368 8/19 (42%)
COG5048 490..>556 CDD:227381 23/96 (24%)
C2H2 Zn finger 494..514 CDD:275368 9/19 (47%)
C2H2 Zn finger 522..542 CDD:275368 5/25 (20%)
C2H2 Zn finger 550..570 CDD:275368 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146678
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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