DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and MYNN

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	454	Identity:	114/454 - (25%)
Similarity:	186/454 - (40%)	Gaps:	102/454 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HVNISSQTCRVCLETH---ETNLYVHDEIKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNC 68
            ::.::.|||.:.|..:   |.:....|.|:.|..:..|.:......|.|..:..|...    ||
Human   135 NIELNQQTCLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTKKKKKAFNSPKTG----QN- 194

  Fly    69 ARRLIGAYEFIVEVENAHETLQNLFEQQEVAAK--PDEVHVDVVELIDQDDVVSMAQYLSTSFAE 131
                       ..|:...:.|:|...:..:.|.  |..| |:.|..|:.:..:.:...:..:|..
Human   195 -----------KTVQYPSDILENASVELFLDANKLPTPV-VEQVAQINDNSELELTSVVENTFPA 247

  Fly   132 QH----VEMEEKYG--DQDCS----AFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELS 186
            |.    |.::.|.|  ..:|:    :.::....:..|.:|:..:|.:..:. |.:|
Human   248 QDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQRYS-KAKP--------- 302

  Fly   187 RPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRH------------------FSQAHKLTADVA 233
                             .|..|.:||:::.||.||                  |:|.::|...|
Human   303 -----------------MCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHV- 349

  Fly   234 AMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPH 298
                 ....|.....||.|.:.|.::..|..|.:..|.:                  .|...|..
Human   350 -----RTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGE------------------EKPYKCDV 391

  Fly   299 CGLSFPVSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQN 362
            |.|.|..|| |.||.|:|:|:.||.||:|.:.|.::..|:.|:|:||||:|..|..|.|.|...:
Human   392 CNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSS 456

  Fly   363 KLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNR 426
            .|..|.|.|||::||.|.:|.|||:.|.:|..|.|.||||||:.|.:||.|:....:|..|:.:
Human   457 SLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	15/80 (19%)
		C2H2 Zn finger	205..226	CDD:275368	10/38 (26%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	44/97 (45%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	12/23 (52%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		6/43 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		2/15 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		1/4 (25%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-C2H2	304..324	CDD:306579	8/19 (42%)
		zf-H2C2_2	316..341	CDD:316026	5/24 (21%)
		C2H2 Zn finger	332..352	CDD:275368	4/25 (16%)
		zf-H2C2_2	345..369	CDD:316026	7/29 (24%)
		SFP1	<354..438	CDD:227516	30/101 (30%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	10/19 (53%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
		zf-H2C2_2	430..453	CDD:316026	11/22 (50%)
		SFP1	<439..522	CDD:227516	36/82 (44%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	473..493	CDD:275368	9/19 (47%)
		C2H2 Zn finger	501..522	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		114/454 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910