DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3281 and ZNF415

DIOPT Version :9

Sequence 1:NP_650132.1 Gene:CG3281 / 41445 FlyBaseID:FBgn0260741 Length:538 Species:Drosophila melanogaster
Sequence 2:XP_024307363.1 Gene:ZNF415 / 55786 HGNCID:20636 Length:678 Species:Homo sapiens


Alignment Length:578 Identity:154/578 - (26%)
Similarity:224/578 - (38%) Gaps:158/578 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 VCLETHETNLYVHD--EIKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNC----------- 68
            |.||.||.    ||  |..:.::|       :.:......|.|..      :||           
Human   194 VTLEQHEK----HDIEEFCFREIK-------KKIHDFDCQWRDDE------RNCNKVTTAPKENL 241

  Fly    69 -------ARRLIG--------AYEFIVEVENAHETLQNLFEQQEVAAKPDEV-HVDVVELIDQDD 117
                   .||.||        ...|:   .:.||     .:|.:...|..|. ||:  :.::...
Human   242 TCRRDQRDRRGIGNKSIKHQLGLSFL---PHPHE-----LQQFQAEGKIYECNHVE--KSVNHGS 296

  Fly   118 VVSMAQYLSTSFAEQHVEMEEKYG-DQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKP-RPDEI 180
            .||..|.:|::. :.||  ..||| |..||:..:              .|.:...:.|| |..|.
Human   297 SVSPPQIISSTI-KTHV--SNKYGTDFICSSLLT--------------QEQKSCIREKPYRYIEC 344

  Fly   181 ENRELSRPSQLGSR-LNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGT 244
            : :.|:..|.:..| ::||....|||.:|.:||::..:|.||: :.|               .|.
Human   345 D-KALNHGSHMTVRQVSHSGEKGYKCDLCGKVFSQKSNLARHW-RVH---------------TGE 392

  Fly   245 GLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRI----------AKRRDCPHC 299
            ....|..|.|:|.|...|..|.:. |......:..|.....:|...          .|...|..|
Human   393 KPYKCNECDRSFSRNSCLALHRRV-HTGEKPYKCYECDKVFSRNSCLALHQKTHIGEKPYTCKEC 456

  Fly   300 GLSFPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNK 363
            |.:|.| |:||.|...|:|..||||::|.|.|.::..|:.|.|.||||:|.:|..|.|.|...:.
Human   457 GKAFSVRSTLTNHQVIHSGKKPYKCNECGKVFSQTSSLATHQRIHTGEKPYKCNECGKVFSQTSS 521

  Fly   364 LARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESF-------------- 414
            ||||.|:|||::||.|..|.|.|..::.|..|.|.||||:||:|..||::|              
Human   522 LARHWRIHTGEKPYKCNECGKVFSYNSHLASHRRVHTGEKPYKCNECGKAFSVHSNLTTHQVIHT 586

  Fly   415 --------VCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPE 471
                    .||...::|.:...|  .||...|       .||   :.|:.......|..|.|   
Human   587 GEKPYKCNQCGKGFSVHSSLTTH--QVIHTGE-------KPY---KCNECGKSFSVRPNLTR--- 636

  Fly   472 NQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSHYEIERVYENPFGKN 529
               .|.:....||      |||..|.:.|      :|..|...| :|....|.|:.:|
Human   637 ---HQIIHTGKKP------YKCSDCGKSF------SVRPNLFRH-QIIHTKEKPYKRN 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3281NP_650132.1 zf-AD 14..92 CDD:285071 20/102 (20%)
C2H2 Zn finger 205..226 CDD:275368 7/20 (35%)
C2H2 Zn finger 249..266 CDD:275368 6/16 (38%)
COG5048 <294..>391 CDD:227381 44/97 (45%)
C2H2 Zn finger 296..315 CDD:275368 9/19 (47%)
zf-H2C2_2 307..330 CDD:290200 11/22 (50%)
C2H2 Zn finger 323..343 CDD:275368 7/19 (37%)
zf-H2C2_2 335..358 CDD:290200 11/22 (50%)
C2H2 Zn finger 351..371 CDD:275368 9/19 (47%)
zf-H2C2_2 364..388 CDD:290200 14/23 (61%)
C2H2 Zn finger 379..399 CDD:275368 7/19 (37%)
zf-H2C2_2 391..416 CDD:290200 13/46 (28%)
C2H2 Zn finger 407..424 CDD:275368 6/38 (16%)
ZNF415XP_024307363.1 KRAB 51..91 CDD:307490
COG5048 <235..497 CDD:227381 75/306 (25%)
C2H2 Zn finger 343..361 CDD:275368 4/18 (22%)
COG5048 367..>662 CDD:227381 101/341 (30%)
C2H2 Zn finger 369..389 CDD:275368 7/20 (35%)
C2H2 Zn finger 397..417 CDD:275368 7/20 (35%)
C2H2 Zn finger 425..445 CDD:275368 2/19 (11%)
C2H2 Zn finger 453..473 CDD:275368 9/19 (47%)
C2H2 Zn finger 481..501 CDD:275368 7/19 (37%)
C2H2 Zn finger 509..529 CDD:275368 9/19 (47%)
C2H2 Zn finger 537..557 CDD:275368 7/19 (37%)
C2H2 Zn finger 565..585 CDD:275368 4/19 (21%)
C2H2 Zn finger 593..613 CDD:275368 5/21 (24%)
C2H2 Zn finger 621..641 CDD:275368 5/25 (20%)
C2H2 Zn finger 649..669 CDD:275368 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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