DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZBTB7B

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_016856888.1	Gene:	ZBTB7B / 51043	HGNCID:	18668	Length:	630	Species:	Homo sapiens

Alignment Length:	449	Identity:	120/449 - (26%)
Similarity:	166/449 - (36%)	Gaps:	110/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEV 105
            |..|||.......|.:..|:|..|   .|.||:   |....:....|.||....:   |..|||
Human   190 LGALLEFAYTATLTTSSANMPAVL---QAARLL---EIPCVIAACMEILQGSGLE---APSPDE- 244

  Fly   106 HVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDV--GEE-----PLYASEDR 163
                      ||.....|||. :||               :|..|.|  ||:     ||......
Human   245 ----------DDCERARQYLE-AFA---------------TATASGVPNGEDSPPQVPLPPPPPP 283

  Fly   164 DDEPEDSFQLKPRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKL 228
            ...|......|||...::.:        |:|.||....:......|..:.:.|...|..|.....
Human   284 PPRPVARRSRKPRKAFLQTK--------GARANHLVPEVPTVPAHPLTYEEEEVAGRVGSSGGSG 340

  Fly   229 TADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIA--------LEPEETTDNS 285
            ..|       :.|..||..:....|::::..:......:..:|.|..        |.|||
Human   341 PGD-------SYSPPTGTASPPEGPQSYEPYEGEEEEEELVYPPAYGLAQGGGPPLSPEE----- 393

  Fly   286 ARKRIAKRRDCPHCGLSFPVSSLTIH--------------IRRHTGDNPYKCDQCEKAFPRSQDL 336
                :....|.....|...:|||  |              :|:.....|.:|..|.|....:..|
Human   394 ----LGSDEDAIDPDLMAYLSSL--HQDNLAPGLDSQDKLVRKRRSQMPQECPVCHKIIHGAGKL 452

  Fly   337 SLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTG 401
            ..|||.||||:|..|::|..:|...:||..|||.|||:|||||..|...|:.|.|||.||..|||
Human   453 PRHMRTHTGEKPFACEVCGVRFTRNDKLKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTG 517

  Fly   402 ERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSED 460
            :|||:|.:|.::|....||  .|:.||.       |.:|          .|..:||.:|
Human   518 DRPYECHLCHKAFAKEDHL--QRHLKGQ-------NCLE----------VRTRRRRKDD 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	15/50 (30%)
		C2H2 Zn finger	205..226	CDD:275368	4/20 (20%)
		C2H2 Zn finger	249..266	CDD:275368	1/16 (6%)
		COG5048	<294..>391	CDD:227381	39/110 (35%)
		C2H2 Zn finger	296..315	CDD:275368	6/32 (19%)
		zf-H2C2_2	307..330	CDD:290200	8/36 (22%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	14/23 (61%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	14/24 (58%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
ZBTB7B	XP_016856888.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000