DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Zfp133

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001019484.2	Gene:	Zfp133 / 499900	RGDID:	1566283	Length:	544	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	134/546 - (24%)
Similarity:	191/546 - (34%)	Gaps:	194/546 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EFIVEVENAHETLQNLFEQQEVAAKPDEV-------HVDVVELIDQDDVVS--MAQYLSTSF--- 129
            :.|.::|...||.:...:..:||. |.:.       ||...:|.:|...|.  ::.:....|
  Rat    68 KLITQLEQGKETWREERKCPQVAC-PAQAKLELCPGHVCPPDLTNQKSPVQHVLSHHAPLIFTCL 131

  Fly   130 -AEQHVEMEEKYGDQDCSAFTSDVGEEPLYASEDRD---DEPEDSFQLKPRPDEIENRE-----L 185
             ||.||:.    ||....|.      |..:.:.|::   |:.|...:...||.....::     |
  Rat   132 CAESHVDR----GDSCQGAL------EKQHQASDKNSCRDKSEGGERESARPSSGRTKKGSLGAL 186

  Fly   186 SRPSQLGSRLN------------------------------------------------------ 196
            |||.| |..:|
  Rat   187 SRPPQ-GQPVNSPNGIRWVEMETSPAQARSTEEPEKLLKGIEILEFGTVNCEECGLGFSKMTNLL 250

  Fly   197 -----HSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTF 256
                 ||....|.|.||.:.|:..:||.|| .:||.               |...:.|:.|.|.|
  Rat   251 SHQRIHSGEKPYVCGVCEKGFSLKKSLARH-QKAHS---------------GEKPIVCKECWRGF 299

  Fly   257 KRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSF-PVSSLTIHIRRHTGDNP 320
            .|:.||..|              |.|.:..:..:     |..||..| ..|:|.||.|.|:|:.|
  Rat   300 SRKSTLIIH--------------ERTHSGEKPYM-----CSECGRGFSQKSNLIIHQRTHSGEKP 345

  Fly   321 YKCDQCEKAF-----------------------------PRSQDLSLHMRQHTGERPSECKICSK 356
            |.|.:|.|.|                             .||..:| |.|.|:||:|..||.|.:
  Rat   346 YVCRECGKGFSQKSAVVRHESTHLEEKTFLCSDCGLGFSDRSNFIS-HQRTHSGEKPYACKECGQ 409

  Fly   357 KFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLN 421
            .|..:..|..|.|.|:.::||.|.:|..||.|::.|..|.|.||||:||.|||||..|...||||
  Rat   410 CFRQRTTLVNHQRTHSKEKPYVCGICGHSFSQNSTLISHRRMHTGEKPYVCGVCGRGFSLKSHLN 474

  Fly   422 IHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDV 486
            .|:|        |...|       .|.|.....:..|:....:|.||....            :.
  Rat   475 RHQN--------IHSGE-------KPIVCKDCGRGFSQQSNLIRHQRTHSG------------EK 512

  Fly   487 PAMCYKCG---------VCEQKFKSG 503
            |.:|.:||         :..|:..||
  Rat   513 PIVCEECGRGFSQKSNLIAHQRTHSG 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	4/14 (29%)
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	7/16 (44%)
		COG5048	<294..>391	CDD:227381	41/126 (33%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	9/48 (19%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	10/23 (43%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:290200	15/24 (63%)
		C2H2 Zn finger	407..424	CDD:275368	10/16 (63%)
Zfp133	NP_001019484.2	KRAB	21..80	CDD:214630	3/11 (27%)
		KRAB	21..60	CDD:279668
		COG5048	235..>530	CDD:227381	98/357 (27%)
		C2H2 Zn finger	236..256	CDD:275368	0/19 (0%)
		zf-H2C2_2	248..272	CDD:290200	6/23 (26%)
		C2H2 Zn finger	264..284	CDD:275368	8/20 (40%)
		C2H2 Zn finger	292..312	CDD:275368	9/33 (27%)
		zf-H2C2_2	305..329	CDD:290200	8/42 (19%)
		zf-C2H2	318..340	CDD:278523	9/26 (35%)
		C2H2 Zn finger	320..340	CDD:275368	9/19 (47%)
		zf-H2C2_2	332..357	CDD:290200	12/24 (50%)
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		C2H2 Zn finger	376..396	CDD:275368	5/20 (25%)
		zf-H2C2_2	388..413	CDD:290200	11/25 (44%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	417..441	CDD:290200	10/23 (43%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		zf-H2C2_2	445..468	CDD:290200	14/22 (64%)
		C2H2 Zn finger	460..480	CDD:275368	12/27 (44%)
		zf-H2C2_2	472..497	CDD:290200	9/39 (23%)
		zf-C2H2	487..508	CDD:278523	5/20 (25%)
		C2H2 Zn finger	488..508	CDD:275368	4/19 (21%)
		zf-H2C2_2	500..525	CDD:290200	7/36 (19%)
		C2H2 Zn finger	516..536	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930