DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Zfp90

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001020936.1	Gene:	Zfp90 / 498945	RGDID:	1563077	Length:	633	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	129/500 - (25%)
Similarity:	192/500 - (38%)	Gaps:	167/500 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EPEDSFQLKPRPDE-IENRELSRP---------------SQLG-SRLNHSANFIYKCAVCPRVFA 213
            :||..|:|:...:. |..|||.||               ||.| |.::|||| ::..|....::.
  Rat    59 KPEVIFKLEQGEEPWISERELQRPFCPDWKTRPDIKSWSSQQGVSEVSHSAN-VWSHATFGDIWG 122

  Fly   214 -----KSESLTRHF----SQAHKLTA------------------------DVAAMKLANESCGT- 244
                 ..||..||.    |...|:||                        ||:: .:....|.|
  Rat   123 VNTQRHQESWRRHLGPEASSQKKITALEKIAEQNKFGEDSGLSTDLVPQLDVSS-SIRPSECKTF 186

  Fly   245 --------GLLT------------CEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDN---SA 286
                    .|:|            |:.|.::|..:.:|.:|.:....||.:    ..||.   |.
  Rat   187 GNNLEYNSELVTQSGIPAKKKPYKCDKCRKSFIHRSSLNKHEKIHKDDAYS----NGTDQGVPSG 247

  Fly   287 RKRIAKRRDCPHCGLSFP-VSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSE 350
            |    |..:|..||.:|. .:.||.|.|.|||:.|::|:.|.|||..|..|..|...||||:|.:
  Rat   248 R----KHHECTDCGKTFLWRTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQ 308

  Fly   351 CKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESF- 414
            |.:|.|.|...:.|.:|.|:|||::||.|.:|.:||..|..|..|...|:||:|:||..||::|
  Rat   309 CSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGEKPFQCKECGKAFS 373

  Fly   415 ---------------------VCG----------SHLNIHRNRKGHLIAVIPGNEVEANFAADPY 448
                                 :||          .|:.||:..|       |......:.|.:|.
  Rat   374 RCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSK-------PYQSNNFSIAFEPN 431

  Fly   449 VNARVNQRRSEDIERMRL----------------QRI--------PENQLQQRLENLP--KPDVP 487
            :.....:....|::....                |||        .|..|:|:..:.|  ||
  Rat   432 IPLTQGESVLTDVKSYHCIDCGKDFSHITDFTEHQRIHAGENSYDSEQALRQQSLSHPREKP--- 493

  Fly   488 AMCYKCGVCEQKFKSGALLTVHRNKMSHYEIERVY--ENPFGKNQ 530
               |:|.||.:.||         ...|..|..|::  |.|:..|:
  Rat   494 ---YQCNVCGKAFK---------RSTSFIEHHRIHTGEKPYECNE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	6/29 (21%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	42/97 (43%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	11/46 (24%)
		C2H2 Zn finger	407..424	CDD:275368	8/48 (17%)
Zfp90	NP_001020936.1	KRAB	14..74	CDD:214630	4/14 (29%)
		KRAB	14..53	CDD:279668
		COG5048	198..625	CDD:227381	97/358 (27%)
		C2H2 Zn finger	211..231	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..290	CDD:290200	13/23 (57%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	321..346	CDD:290200	12/24 (50%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	349..374	CDD:290200	11/24 (46%)
		C2H2 Zn finger	365..385	CDD:275368	4/19 (21%)
		zf-H2C2_2	377..400	CDD:290200	2/22 (9%)
		C2H2 Zn finger	393..413	CDD:275368	3/19 (16%)
		C2H2 Zn finger	449..469	CDD:275368	2/19 (11%)
		C2H2 Zn finger	496..516	CDD:275368	8/28 (29%)
		zf-H2C2_2	511..533	CDD:290200	5/15 (33%)
		C2H2 Zn finger	524..544	CDD:275368	1/2 (50%)
		zf-H2C2_2	536..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		zf-H2C2_2	564..587	CDD:290200
		C2H2 Zn finger	580..600	CDD:275368
		zf-H2C2_2	596..617	CDD:290200
		C2H2 Zn finger	608..628	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930