DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF705A

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_024304748.1	Gene:	ZNF705A / 440077	HGNCID:	32281	Length:	315	Species:	Homo sapiens

Alignment Length:	188	Identity:	61/188 - (32%)
Similarity:	93/188 - (49%)	Gaps:	31/188 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 RQDTL-RRHMQAFHP----DA----------IALEPEETTDNSARKRIAKRRDCPHCGLSFPVSS 307
            |:..| ::||.:.||    ||          |..:|.|..|:.        .||.|.      |:
Human    95 RESALKKKHMISMHPITRKDASTSMTMENSLILEDPFECNDSG--------EDCTHS------ST 145

  Fly   308 LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHT 372
            :|..:..|:|..||...||.|:.........|.:.||..:..:|.:|.|.:.:..:|.||...||
Human   146 ITQRLLTHSGKKPYVSKQCGKSLRNLFSPKPHKQIHTKGKSYQCNLCEKAYTNCFRLRRHKMTHT 210

  Fly   373 GQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHL 430
            |:|||:|.:|.|:|.|.:.|:.|.:.|||||||:|..||::|:  ...|:.|:.:.||
Human   211 GERPYACHLCGKAFTQCSHLRRHEKTHTGERPYKCHQCGKAFI--QSFNLRRHERTHL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368
		C2H2 Zn finger	249..266	CDD:275368	2/8 (25%)
		COG5048	<294..>391	CDD:227381	32/96 (33%)
		C2H2 Zn finger	296..315	CDD:275368	4/18 (22%)
		zf-H2C2_2	307..330	CDD:290200	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	4/19 (21%)
		zf-H2C2_2	335..358	CDD:290200	6/22 (27%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
ZNF705A	XP_024304748.1	KRAB	22..81	CDD:214630
		C2H2 Zn finger	133..153	CDD:275368	6/33 (18%)
		COG5048	<136..315	CDD:227381	49/147 (33%)
		C2H2 Zn finger	162..181	CDD:275368	4/18 (22%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..226	CDD:316026	13/24 (54%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		zf-H2C2_2	229..254	CDD:316026	13/26 (50%)
		C2H2 Zn finger	245..265	CDD:275368	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930