DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF805

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	463	Identity:	125/463 - (26%)
Similarity:	178/463 - (38%)	Gaps:	93/463 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NCARRLIGAYEFIVEVENAHE--TLQNLFEQQEVAAKPDEVH--VDVVELIDQDDVVSMAQYLST 127
            :|.....|....|.|.||..:  ..:.:|.::.:.|:.:.:|  |...|..:.....|.:.||.
Human   184 DCDSHGSGKNPVIQEEENIFKCNECEKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLL- 247

  Fly   128 SFAEQH--VEMEEK-YGDQDC-SAFTS----------DVGEEPLYASE--------------DRD 164
                ||  |...|| |...:| .||..          ..||:|...||              :|.
Human   248 ----QHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRS 308

  Fly   165 DEPEDSFQLKPRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLT 229
            ...|..|..|    |.......||..:...:.||....|:|..|.:||.....|..| .|.|...
Human   309 HTGEKPFVCK----ECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWH-QQTHTGE 368

  Fly   230 ADVAAMKLANESCGTGLL-------------TCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEET 281
            ......:.....|.:..|             .|..|.:.|..:..|:|| |..|..
Human   369 KPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRH-QRIHTG--------- 423

  Fly   282 TDNSARKRIAKRRDCPHCGLSFP-VSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTG 345
                     .|...|..||.:|. .|:..:|.|.|||:.|::|.:|.|||....||..|...|||
Human   424 ---------EKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTG 479

  Fly   346 ERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVC 410
            |:|.||..|.|.|..::.|.||.|:|:|::||.|..|.|:|..|.:|..|...||||:||:|..|
Human   480 EKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIHTGEKPYECSEC 544

  Fly   411 GESFVCGSHLNIH-RNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQR------ 468
            |::|...|.|..| |...|.       |.:.......|:.:.:.    |.:|:.:.|.:
Human   545 GKAFSRSSSLTQHQRMHTGR-------NPISVTDVGRPFTSGQT----SVNIQELLLGKNFLNVT 598

  Fly   469 IPENQLQQ 476
            ..||.||:
Human   599 TEENLLQE 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	6/26 (23%)
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	42/97 (43%)
		C2H2 Zn finger	296..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..330	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	12/22 (55%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	7/17 (41%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162
		COG5048	192..568	CDD:227381	115/411 (28%)
		C2H2 Zn finger	205..225	CDD:275368	2/19 (11%)
		zf-H2C2_2	218..241	CDD:290200	4/22 (18%)
		C2H2 Zn finger	233..253	CDD:275368	5/24 (21%)
		zf-H2C2_2	245..270	CDD:290200	11/29 (38%)
		C2H2 Zn finger	261..281	CDD:275368	3/19 (16%)
		zf-H2C2_2	273..298	CDD:290200	5/24 (21%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		zf-H2C2_2	305..324	CDD:290200	5/22 (23%)
		C2H2 Zn finger	317..337	CDD:275368	4/23 (17%)
		zf-C2H2	343..365	CDD:278523	8/22 (36%)
		C2H2 Zn finger	345..365	CDD:275368	7/20 (35%)
		zf-H2C2_2	357..380	CDD:290200	4/23 (17%)
		C2H2 Zn finger	373..393	CDD:275368	2/19 (11%)
		zf-C2H2	399..421	CDD:278523	7/22 (32%)
		C2H2 Zn finger	401..421	CDD:275368	7/20 (35%)
		zf-H2C2_2	413..438	CDD:290200	10/43 (23%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-H2C2_2	445..466	CDD:290200	11/20 (55%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		zf-H2C2_2	469..494	CDD:290200	13/24 (54%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	498..520	CDD:290200	11/21 (52%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	525..550	CDD:290200	12/24 (50%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930